唐氏综合征成年患者脉络膜厚度增加。
Increased choroidal thickness in adults with Down syndrome.
作者信息
Csincsik Lajos, Nelson Rachel, Walpert Madeleine J, Peto Tunde, Holland Anthony, Lengyel Imre
机构信息
Wellcome-Wolfson Institute for Experimental Medicine Queen's University Belfast Belfast UK.
Department of Psychiatry University of Cambridge, Cambridge Intellectual and Developmental Disabilities Research Group Cambridge UK.
出版信息
Alzheimers Dement (Amst). 2021 Mar 17;13(1):e12170. doi: 10.1002/dad2.12170. eCollection 2021.
INTRODUCTION
People with Down syndrome (DS) are particularly susceptible to Alzheimer's disease (AD) due to the triplication of the amyloid precursor protein () gene. In this cross-sectional study, we hypothesized that choroidal thinning reported in sporadic AD (sAD) is mirrored in adults with DS.
METHODS
The posterior pole of the eye for 24 adults with DS and 16 age-matched controls (Ctrl) were imaged with optical coherence tomography. Choroidal thickness (ChT) was measured and analyzed in relation to cognitive status and cerebral amyloid beta (Aβ) load.
RESULTS
ChT was increased in people with DS (pwDS) compared to Ctrl. This increase was associated with gender differences and positively correlated with cerebral Aβ load in a small subset. There was no significant correlation detected between ChT and age or cognitive status.
DISCUSSION
In contrast to sAD this study found a significantly thicker choroid in pwDS. Whether these changes are related to Aβ pathology in DS needs further investigation.
引言
由于淀粉样前体蛋白（APP）基因的三倍体，唐氏综合征（DS）患者特别容易患阿尔茨海默病（AD）。在这项横断面研究中，我们假设散发性AD（sAD）中报告的脉络膜变薄在DS成人中也存在。
方法
对24名DS成人和16名年龄匹配的对照（Ctrl）的眼后极进行光学相干断层扫描成像。测量并分析脉络膜厚度（ChT）与认知状态和脑淀粉样β（Aβ）负荷的关系。
结果
与Ctrl相比，DS患者（pwDS）的ChT增加。这种增加与性别差异有关，并且在一小部分人群中与脑Aβ负荷呈正相关。未检测到ChT与年龄或认知状态之间存在显著相关性。
讨论
与sAD相反，本研究发现pwDS的脉络膜明显更厚。这些变化是否与DS中的Aβ病理相关需要进一步研究。
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