认知功能减退受试者视网膜淀粉样蛋白成像的扇形分割
Sectoral segmentation of retinal amyloid imaging in subjects with cognitive decline.
作者信息
Dumitrascu Oana M, Lyden Patrick D, Torbati Tania, Sheyn Julia, Sherzai Ayesha, Sherzai Dean, Sherman Dale S, Rosenberry Ryan, Cheng Susan, Johnson Kenneth O, Czeszynski Alan D, Verdooner Steven, Frautschy Sally, Black Keith L, Koronyo Yosef, Koronyo-Hamaoui Maya
机构信息
Department of Neurology Cedars-Sinai Medical Center Los Angeles California USA.
Department of Neurosurgery Cedars-Sinai Medical Center Los Angeles California USA.
出版信息
Alzheimers Dement (Amst). 2020 Sep 28;12(1):e12109. doi: 10.1002/dad2.12109. eCollection 2020.
INTRODUCTION
Despite advances in imaging retinal amyloidosis, a quantitative and topographical investigation of retinal amyloid beta burden in patients with cognitive decline has never been reported.
METHODS
We used the specific amyloid-binding fluorophore curcumin and laser ophthalmoscopy to assess retinal amyloid imaging (RAI) in 34 patients with cognitive decline. We automatically quantified retinal amyloid count (RAC) and area in the superotemporal retinal sub-regions and performed correlation analyses with cognitive and brain volumetric parameters.
RESULTS
RAC significantly and inversely correlated with hippocampal volume (HV; r = -0.39, = .04). The proximal mid-periphery (PMP) RAC and RA areas were significantly greater in patients with Montreal Cognitive Assessment (MOCA) score < 26 ( = .01; Cohen d = 0.83 and 0.81, respectively). PMP showed significantly more RAC and area in subjects with amnestic mild cognitive impairment (MCI) and Alzheimer's disease (AD) compared to cognitively normal ( = .04; Cohen d = 0.83).
CONCLUSION
Quantitative RAI is a feasible technique and PMP RAC may predict HV. Future larger studies should determine RAI's potential as a biomarker of early AD.
引言
尽管视网膜淀粉样变性成像技术有所进步，但从未有过关于认知功能减退患者视网膜β淀粉样蛋白负荷的定量和地形图研究报道。
方法
我们使用特异性淀粉样蛋白结合荧光团姜黄素和激光检眼镜评估了34例认知功能减退患者的视网膜淀粉样蛋白成像（RAI）。我们自动量化了视网膜颞上象限子区域的视网膜淀粉样蛋白计数（RAC）和面积，并与认知及脑容量参数进行了相关性分析。
结果
RAC与海马体积（HV）显著负相关（r = -0.39，P = 0.04）。蒙特利尔认知评估量表（MOCA）评分<26分的患者，其近周边中部（PMP）的RAC和RA面积显著更大（P = 0.01；Cohen d分别为0.83和0.81）。与认知正常者相比，遗忘型轻度认知障碍（MCI）和阿尔茨海默病（AD）患者的PMP显示出显著更多的RAC和面积（P = 0.04；Cohen d = 0.83）。
结论
定量RAI是一种可行的技术，PMP RAC可能预测HV。未来更大规模的研究应确定RAI作为早期AD生物标志物的潜力。
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