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饮用水中砷暴露与高血压的剂量反应荟萃分析。

Dose-response meta-analysis of arsenic exposure in drinking water and hypertension.

作者信息

Amiri Afsaneh, Mokhayeri Yaser, Mohammadi Rasool, Karami Mohammad Amin, Ghaderpoori Mansour, Kamarehie Bahram, Jafari Ali

机构信息

Department of Environmental Health Engineering, Environmental Health Research Center, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran.

Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khorramabad, Iran.

出版信息

Heliyon. 2021 Mar 12;7(3):e06409. doi: 10.1016/j.heliyon.2021.e06409. eCollection 2021 Mar.

DOI:10.1016/j.heliyon.2021.e06409
PMID:33748480
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7970273/
Abstract

BACKGROUND

Based on the cross-sectional and cohort studies, exposure to As via drinking water can cause hypertension.

METHODS

We searched PubMed, ISI WOS, and Scopus for relevant studies up to 1 January 2018 using related keywords. The meta-analysis was done on 10 studies (n = 28255) that report Odds Ratio for hypertension. The extracted ORs between As concentration and hypertension were pooled using random effect models. Study heterogeneity was analyzed using .

RESULTS

The estimated adjusted OR for association between As and hypertension was 1.44 (95% CI: 1.12, 1.84) with = 71%. Dose-Response analysis showed a linear relationship between As and hypertension (OR = 1.0008 95% CI: 1.0003, 1.001). In general, by increase of each unit in arsenic concentration, odds of the hypertension would increase as 0.08%.

CONCLUSION

There was a significant relationship between As exposure and hypertension.

摘要

背景

基于横断面研究和队列研究，通过饮用水接触砷可导致高血压。

方法

我们使用相关关键词在PubMed、ISI WOS和Scopus数据库中检索截至2018年1月1日的相关研究。对10项报告高血压比值比的研究（n = 28255）进行荟萃分析。使用随机效应模型汇总砷浓度与高血压之间提取的比值比。使用 分析研究异质性。

结果

砷与高血压之间关联的估计调整比值比为1.44（95%置信区间：1.12，1.84）， = 71%。剂量反应分析显示砷与高血压之间存在线性关系（比值比 = 1.0008，95%置信区间：1.0003，1.001）。一般来说，砷浓度每增加一个单位，高血压的几率将增加0.08%。

结论

砷暴露与高血压之间存在显著关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aa3/7970273/ffa94f5fa439/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aa3/7970273/7a4d3b180e56/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aa3/7970273/da1e0554f2d4/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aa3/7970273/e743518cc701/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aa3/7970273/de8458a2ade0/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aa3/7970273/ffa94f5fa439/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aa3/7970273/7a4d3b180e56/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aa3/7970273/da1e0554f2d4/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aa3/7970273/e743518cc701/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aa3/7970273/de8458a2ade0/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aa3/7970273/ffa94f5fa439/gr5.jpg

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A pilot study of low-moderate drinking water arsenic contamination and chronic diseases among reproductive age women in Timiş County, Romania.罗马尼亚蒂米什县育龄妇女中低中度饮用水砷污染与慢性病的一项试点研究。
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