Krishna Vinay Narasimha, Ahmad Masood, Overton Edgar T, Jain Gaurav
Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL.
Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL.
Kidney Med. 2021 May-Jun;3(3):447-450. doi: 10.1016/j.xkme.2021.02.004. Epub 2021 Mar 17.
Patients receiving in-center hemodialysis are at high risk for infections due to relative immunosuppression, limited ability to physically distance, and frequent encounters with the health care setting. This has been particularly evident during the coronavirus disease 2019 (COVID-19) pandemic. We describe 2 patients with suspected recurrent COVID-19 infection, each with documented clearance of virus between episodes. The duration between a negative reverse-transcription polymerase chain reaction test result for severe acute respiratory syndrome coronavirus 2 and symptomatic reinfection was 31 and 55 days, respectively, in the 2 patients. A higher risk for infection with COVID-19 and poor outcomes if infected, including ≥20% short-term mortality risk, is worrisome in this patient population. Continued measures such as infection prevention, community outreach, and early testing may play a role in establishing protocols to protect the vulnerable dialysis population.
接受中心血液透析的患者由于相对免疫抑制、身体保持距离的能力有限以及频繁接触医疗环境,因而感染风险很高。这在2019年冠状病毒病(COVID-19)大流行期间尤为明显。我们描述了2例疑似COVID-19反复感染的患者,每例在两次发作之间都有病毒清除的记录。在这2例患者中,严重急性呼吸综合征冠状病毒2的逆转录聚合酶链反应检测结果呈阴性与症状性再感染之间的间隔时间分别为31天和55天。在这一患者群体中,感染COVID-19的风险较高,且感染后预后较差,包括短期死亡风险≥20%,这令人担忧。诸如感染预防、社区宣传和早期检测等持续措施可能在制定保护脆弱透析人群的方案中发挥作用。