用于基于磁共振成像检测严重急性呼吸综合征冠状病毒2的磁性微器件

Magnetic Microdevices for MRI-Based Detection of SARS-CoV-2 Viruses.

作者信息

Mair Lamar O, Hale Olivia, Jafari Sahar, Chen Cheng, Udalov Oleg, Probst Roland, Baum Ittai, Hevaganinge Anjana, Yi Wang Elaine, Rodriguez Olga C, Albanese Christopher, Fricke Stanley T, Weinberg Irving N

机构信息

Neuroparticle Corporation, North Bethesda, MD, USA.

Weinberg are with Shape Theranostics, Inc. and Weinberg Medical Physics, Inc., North Bethesda, MD, USA.

出版信息

IEEE Open J Eng Med Biol. 2020;1:265-267. doi: 10.1109/ojemb.2020.3026234. Epub 2020 Sep 24.

DOI:10.1109/ojemb.2020.3026234

PMID:33748768

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7978173/

Abstract

GOAL

To develop a micron-scale device that can operate as an MRI-based reporter for the presence of SARS-CoV-2 virus.

METHODS

Iron rod microdevices were constructed via template-guided synthesis and suspended in phosphate buffered saline (PBS). Heat-inactivated SARS-CoV-2 viruses were added to the samples and imaged with low-field MRI.

RESULTS

MRI of microdevices and viruses showed decreased signal intensity at low concentrations of viruses that recovered at higher concentrations. Electron micrographs suggest that reduced MRI intensity may be due to concentration-dependent shielding of water protons from local magnetic inhomogeneities caused by the iron microdevices.

CONCLUSIONS

The preliminary results presented in this letter provide justification for further studies exploring the potential diagnostic role of magnetic microdevices in assessing the presence and concentration of SARS-CoV-2 viruses.

摘要