Fernandes-Matano Larissa, Monroy-Muñoz Irma Eloisa, Uribe-Noguez Luis Antonio, Hernández-Cueto María de Los Ángeles, Sarquiz-Martínez Brenda, Pardavé-Alejandre Héctor Daniel, Coy-Arechavaleta Andrea Santos, Alvarado-Yaah Julio Elías, Rojas-Mendoza Teresita, Santacruz-Tinoco Clara Esperanza, Grajales-Muñiz Concepción, Borja-Aburto Víctor Hugo, Muñoz-Medina José Esteban
Instituto Mexicano del Seguro Social, División de Laboratorios de Vigilancia e Investigación Epidemiológica, Laboratorio Central de Epidemiología. Ciudad de México, México.
Instituto Nacional de Perinatología "Isidro Espinoza de los Reyes", Departamento de Genética y Genómica Humana, Laboratorio de Genómica. Ciudad de México, México.
Rev Med Inst Mex Seguro Soc. 2021 Nov 1;59(6):482-489.
SARS-CoV-2 is a coronavirus described for the first time in China, in December 2019. This virus can cause a disease with a very variable spectrum that ranges from asymptomatic cases to deaths. The most severe cases are normally associated with comorbidities and with the age of the patient. However, there are patients who are not part of these risk groups and develop severe cases.
To determine the association between coinfections by SARS-CoV-2 and other respiratory viruses and their clincal outcome.
RT-qPCR was performed to determine the presence of 16 respiratory viruses in 103 confirmed COVID-19 cases. Demographic and comorbid data were collected, and statistical analyzes were performed to determine associations with severity.
Of the 103 analyzed cases, 14 (13.6%) presented a coinfection, of these, 92% did not require hospitalization, even in those cases in which the patient presented advanced age and some comorbidities.
These results suggest that coinfection of SARS-CoV-2 and other respiratory viruses is not related to a more severe form of COVID-19 and, in some cases, depending on the virus involved, it could even lead to a better prognosis. These findings lay the foundations for the development of new studies that could determine the biological mechanism of this phenomenon.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）是2019年12月在中国首次发现的一种冠状病毒。这种病毒可引发一系列症状表现差异很大的疾病，从无症状感染到死亡。最严重的病例通常与合并症及患者年龄有关。然而，也有一些不属于这些风险群体的患者会发展为重症病例。
确定SARS-CoV-2与其他呼吸道病毒合并感染与其临床结局之间的关联。
对103例确诊的新冠肺炎病例进行逆转录定量聚合酶链反应（RT-qPCR），以确定16种呼吸道病毒的存在情况。收集人口统计学和合并症数据，并进行统计分析以确定与疾病严重程度的关联。
在103例分析病例中，14例（13.6%）出现合并感染，其中92%的患者无需住院治疗，即使是那些年龄较大且有一些合并症的患者。
这些结果表明，SARS-CoV-2与其他呼吸道病毒的合并感染与新冠肺炎更严重的形式无关，在某些情况下，取决于所涉及的病毒，甚至可能导致更好的预后。这些发现为开展新的研究奠定了基础，这些研究可能会确定这一现象的生物学机制。
