Department of Medical Oncology, Habib Bourguiba Hospital University of Sfax, 3029, Sfax, Tunisia.
J Cancer Res Clin Oncol. 2021 Nov;147(11):3401-3407. doi: 10.1007/s00432-021-03600-y. Epub 2021 Mar 21.
The use of complementary and alternative medicine (CAM) is common among breast cancer patients, but less is known about whether CAM influences breast cancer survival. The primary aim of this study was to determine the impact of self-use of herbs on the overall survival.
This was a prospective study including 110 patients with breast cancer. All patients were questioned about the concept of taking herbs. We analyzed the demographic data and the overall survival.
The average age was 51 years (30-80 years old). 37 had metastatic disease (33.6%). 48 patients had taken plants (43.6%). 19 patients consumed Graviola (39.6%) and 29 Alenda (60.4%). Overall survival at 3 years and at 5 years were, respectively, 96.2% and 82.4% in the absence of plant consumption versus 78.5% and 78.5% in case of plant consumption (p = 0.015).
This study concluded that self-medication with Graviola or Alenda may be associated with an increase of death risk in patients with breast cancer. Further studies are needed to confirm these results.
在乳腺癌患者中，使用补充和替代医学（CAM）很常见，但关于 CAM 是否会影响乳腺癌的生存情况知之甚少。本研究的主要目的是确定自我使用草药对整体生存率的影响。
这是一项包括 110 例乳腺癌患者的前瞻性研究。所有患者均被问及服用草药的概念。我们分析了人口统计学数据和整体生存率。
平均年龄为 51 岁（30-80 岁）。37 例患者有转移疾病（33.6%）。48 例患者服用过植物（43.6%）。19 例患者服用 Graviola（39.6%），29 例患者服用 Alenda（60.4%）。在没有植物消耗的情况下，3 年和 5 年的总生存率分别为 96.2%和 82.4%，而在植物消耗的情况下，3 年和 5 年的总生存率分别为 78.5%和 78.5%（p=0.015）。
本研究得出结论，自我使用 Graviola 或 Alenda 可能与乳腺癌患者的死亡风险增加有关。需要进一步的研究来证实这些结果。
