多环倍半萜（±）-耳状醇 A 的非对映选择性形式合成。
Diastereoselective Formal Synthesis of Polycyclic Meroterpenoid (±)-Cochlearol A.
机构信息
Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad 500007, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
出版信息
J Org Chem. 2021 Apr 2;86(7):5412-5416. doi: 10.1021/acs.joc.1c00205. Epub 2021 Mar 22.
PMID:33749282
Abstract
A formal synthesis of (±)-cochlearol A was accomplished. The synthesis features Suzuki coupling and Friedel-Crafts cyclization as a convergent strategy to the functionalized tetralone ring and an intramolecular construction of the C/D ring involving sequential epoxide formation/acetal formation.
摘要
（±）-耳蜗醇 A 的全合成研究。该合成采用 Suzuki 偶联和 Friedel-Crafts 环化作为功能化四氢萘酮环的收敛策略，以及涉及环氧化物形成/缩醛形成的顺序的 C/D 环的分子内构建。
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