构建三羰基化合物的连续反应及其合成应用。
Consecutive reactions to construct tricarbonyl compounds and synthetic applications thereof.
作者信息
Madroñero Diego, Mujica-Martinez Cesar A, Vázquez Alfredo
机构信息
Departamento de Química Orgánica, Facultad de Química, Universidad Nacional Autónoma de México Ciudad Universitaria Cd. Mx. 04510 Mexico
GIFBA, Departamento de Química, Facultad de Ciencias Exactas y Naturales, Centro de Investigación en Materiales CIMA, Universidad de Nariño San Juan de Pasto 520002 Colombia.
出版信息
RSC Adv. 2021 Oct 11;11(53):33235-33244. doi: 10.1039/d1ra05187c. eCollection 2021 Oct 8.
Lithium anions derived from O-carbonate-protected cyanohydrins undergo conjugate addition to cycloalkenones with the concomitant transfer of the alkoxycarbonyl group to produce tricarbonyl compounds. These products offer numerous possibilities for further elaboration. The synthetic potential of the cascade products was demonstrated by forming bicyclic and tricyclic systems through intramolecular condensation reactions.
源自O - 碳酸酯保护的氰醇的锂阴离子与环烯酮发生共轭加成反应，同时将烷氧羰基转移，生成三羰基化合物。这些产物为进一步的精细合成提供了众多可能性。通过分子内缩合反应形成双环和三环体系，证明了级联产物的合成潜力。
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