Department of Cardiology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark.
Fertility Department Rigshospitalet Copenhagen University Hospital Copenhagen Denmark.
J Am Heart Assoc. 2021 Apr 6;10(7):e018314. doi: 10.1161/JAHA.120.018314. Epub 2021 Mar 20.
Background Sudden cardiac death (SCD) constitutes a major health problem worldwide. We investigated whether birth weight (BW), small for gestational age (SGA), and large for gestational age are associated with altered risk of SCD among the young (aged 1-36 years). Methods and Results We included all people born in Denmark from 1973 to 2008 utilizing the Danish Medical Birth Register. All SCDs in Denmark in 2000 to 2009 have previously been identified. We defined 5 BW groups, SGA, and large for gestational age as exposure and SCD as the outcome. We estimated the age-specific relative risk of SCD with 95% CI. Additionally, we investigated if SGA and large for gestational age are associated with pathological findings at autopsy. The study population for the BW analyses comprised 2 234 501 people with 389 SCD cases, and the SGA and large for gestational age analyses comprised 1 786 281 people with 193 SCD cases. The relative risk for SCD was 6.69 for people with BW between 1500 and 2499 g (95% CI, 2.38-18.80, <0.001) and 5.89 for people with BW ≥4500 g (95% CI, 1.81-19.12, =0.003) at age 5 years. BW 2500 to 3400 g was the reference group. Compared with an appropriate gestational age, the relative risk for SGA was 2.85 (95% CI, 1.35-6.00, =0.006) at age 10 years. For the autopsied cases, the relative risk of sudden arrhythmic death syndrome at age 5 years was 4.19 for SGA (95% CI, 1.08-16.22, =0.038). Conclusions We found an association between BW and SCD in the young, with an increased risk among SGA infants. In addition, we found an association between SGA and sudden arrhythmic death syndrome.
背景 心脏性猝死（SCD）是全球范围内的一个重大健康问题。我们研究了出生体重（BW）、小于胎龄儿（SGA）和大于胎龄儿是否与年轻人（年龄 1-36 岁）的 SCD 风险改变有关。
方法和结果 我们纳入了 1973 年至 2008 年期间在丹麦出生的所有人，并利用丹麦医学出生登记处的数据。此前，丹麦 2000 年至 2009 年的所有 SCD 病例均已确定。我们将 5 个 BW 组、SGA 和大于胎龄儿定义为暴露因素，SCD 为结局。我们使用 95%CI 来估计 SCD 的年龄特异性相对风险。此外，我们还研究了 SGA 和大于胎龄儿是否与尸检时的病理发现有关。BW 分析的研究人群包括 2234501 人，有 389 例 SCD 病例，SGA 和大于胎龄儿分析的研究人群包括 1786281 人，有 193 例 SCD 病例。年龄为 5 岁时，BW 为 1500-2499g 的人群的 SCD 相对风险为 6.69（95%CI，2.38-18.80，<0.001），BW 为≥4500g 的人群为 5.89（95%CI，1.81-19.12，=0.003）。BW 为 2500-3400g 的人群为参考组。与适当的胎龄相比，10 岁时 SGA 的相对风险为 2.85（95%CI，1.35-6.00，=0.006）。对于尸检病例，年龄为 5 岁时，SGA 的突发性心律失常死亡综合征的相对风险为 4.19（95%CI，1.08-16.22，=0.038）。
结论 我们发现 BW 与年轻人的 SCD 之间存在关联，SGA 婴儿的风险增加。此外，我们还发现 SGA 与突发性心律失常死亡综合征之间存在关联。
