Clausing Elizabeth S, Binder Alexandra M, Non Amy L
Department of Anthropology at The University of California, San Diego, 92093 CA, USA.
Department of Epidemiology at The University of California, Los Angeles, 90095 CA, USA.
Epigenomics. 2021 Nov;13(21):1677-1699. doi: 10.2217/epi-2019-0343. Epub 2021 Mar 22.
To investigate associations of psychosocial stressors and resilience factors with DNA methylation age in the saliva of Latinx children of immigrants before and after the 2016 presidential election (2015-2018). We compared psychosocial exposures with four distinct measures of epigenetic age assessed in the saliva of children (6-13 years, n = 71 pre-election; n = 35 post-election). Exploratory genome-wide analyses were also conducted. We found distinct associations across epigenetic clocks and time points; for example, greater maternal social status pre-election and fear of parent deportation post-election both associated with decreased Hannum age (p ≤ 0.01). Although limited in size, our unique study design provides novel hypotheses regarding how the social environment may influence epigenetic aging and genome-wide methylation, potentially contributing to racial/ethnic health inequalities.
为了研究2016年总统大选前后（2015 - 2018年），移民家庭的拉丁裔儿童唾液中的心理社会压力源和复原力因素与DNA甲基化年龄之间的关联。我们将心理社会暴露与在儿童唾液中评估的四种不同的表观遗传年龄测量方法进行了比较（6 - 13岁，选举前n = 71；选举后n = 35）。还进行了全基因组探索性分析。我们发现不同的表观遗传时钟和时间点之间存在不同的关联；例如，选举前母亲较高的社会地位和选举后对父母被驱逐出境的恐惧都与汉纳姆年龄的降低有关（p≤0.01）。尽管样本量有限，但我们独特的研究设计为社会环境如何影响表观遗传衰老和全基因组甲基化提供了新的假设，这可能导致种族/民族健康不平等。
