Ogbogu V C, Storey D M
Department of Biological Sciences, University of Salford, UK.
Parasite Immunol. 1988 Mar;10(2):219-35. doi: 10.1111/j.1365-3024.1988.tb00216.x.
Ultrastructural studies revealed that in albino rats Litomosoides carinii was encapsulated and eventually killed in the pleural cavity by adherent host cells. Encapsulation was an organized cellular reaction which sequestered and eventually degraded the parasites. The process evolved in three phases: primary accumulation of host cells, especially eosinophils and macrophages, around the parasites with concentration of eosinophils on the parasite surface; secondary transformation of macrophages into epithelioid cells which replaced eosinophils on the parasite surface; finally, dead parasites became calcified and were gradually degraded within a tough, compacted fibrotic capsule.
超微结构研究显示，在白化大鼠中，卡里尼丝虫被包裹在胸腔内，并最终被黏附的宿主细胞杀死。包裹是一种有组织的细胞反应，它隔离并最终降解寄生虫。这个过程分为三个阶段：宿主细胞，尤其是嗜酸性粒细胞和巨噬细胞，在寄生虫周围初步聚集，嗜酸性粒细胞集中在寄生虫表面；巨噬细胞二次转化为上皮样细胞，取代寄生虫表面的嗜酸性粒细胞；最后，死亡的寄生虫钙化，并在坚韧、致密的纤维化包膜内逐渐降解。
