IgE 依赖的细胞黏附作用及对卡里尼丝虫微丝蚴的细胞毒性——效应细胞的性质
IgE-dependent cellular adhesion and cytotoxicity to Litomosoides carinii microfilariae--nature of effector cells.
作者信息
Mehta K, Sindhu R K, Subrahmanyam D, Hopper K, Nelson D S
出版信息
Clin Exp Immunol. 1982 May;48(2):477-84.
Abstract
Albino rats immunized with sonicated microfilarial antigen incorporated in Freund's complete adjuvant, produce antibodies that promote cell-mediated adhesion and killing of Litomosoides carinii microfilariae in vitro. Using highly purified cell populations, it has been shown that macrophages and neutrophils are most active in this phenomenon. Eosinophils, while adhering readily to parasites in the presence of the antibody, did not affect the viability of the parasites when observed after 24 hr incubation.
摘要
用弗氏完全佐剂中掺入的超声处理微丝蚴抗原免疫的白化大鼠，产生的抗体可促进体外细胞介导的对卡里尼丝虫微丝蚴的黏附与杀伤。利用高度纯化的细胞群体，已表明巨噬细胞和中性粒细胞在此现象中最为活跃。嗜酸性粒细胞虽然在抗体存在下能轻易黏附于寄生虫，但在孵育24小时后观察时，并未影响寄生虫的活力。
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