The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
Department of Andrology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Reprod Biol Endocrinol. 2021 Mar 9;19(1):43. doi: 10.1186/s12958-021-00720-5.
Many infertile couples might experience erectile dysfunction (ED) and significant changes in the quality of sexual life and psychological state though information is limited in secondary infertile men in China. To determine whether primary or secondary infertility is associated with ED, psychological disorders, and sexual performance.
This was a cross-sectional survey conducted at the Dongzhimen Hospital of Beijing University of Chinese Medicine (06/2019-01/2020). The participants completed a questionnaire including general information, sexual life, simplified International Index of Erectile Function (IIEF-5), Patient Health Questionnaire-9 (PHQ-9), and 7-item Generalized Anxiety Disorder Scale (GAD-7). Multivariable logistic regression was used to identify the factors associated with ED, depression, and anxiety.
ED was more frequent in secondary vs. primary infertility (46.5 % vs. 26.7 %, P < 0.001). Compared with men with primary infertility, those with secondary infertility showed lower IIEF-5 scores (P < 0.001), higher occurrence of TOIF (P = 0.001), had a higher awareness of partner's ovulation when having ED (P = 0.001), lower GAD-7 scores (P = 0.016), lower libido (P = 0.005), fewer intercourses per month (P = 0.001) and a lower sexual satisfaction score (P = 0.027). In the multivariate analysis, primary infertility was found to be an independent risk factor of anxiety (OR: 1.812, 95 %CI: 1.015-3.236). Some overlap is observed in factors associated with ED, psychological disorders, and sexual performance between primary and secondary infertility, but some factors are distinct.
The prevalence of ED in secondary infertility men was higher than that of primary infertility men, and the quality of sexual life was decreased. Primary infertility is an independent risk factor of anxiety.
尽管在中国，关于次要不育男性的信息有限，但许多不孕夫妇可能会经历勃起功能障碍（ED）以及性生活质量和心理状态的重大变化。为了确定原发性或继发性不育是否与 ED、心理障碍和性功能有关。
这是一项在北京中医药大学东直门医院进行的横断面调查（2019 年 6 月至 2020 年 1 月）。参与者完成了一份问卷，包括一般信息、性生活、简化国际勃起功能指数（IIEF-5）、患者健康问卷-9（PHQ-9）和 7 项广泛性焦虑症量表（GAD-7）。多变量逻辑回归用于确定与 ED、抑郁和焦虑相关的因素。
与原发性不育相比，继发性不育中 ED 更为常见（46.5%比 26.7%，P<0.001）。与原发性不育男性相比，继发性不育男性 IIEF-5 评分较低（P<0.001），TOIF 发生率较高（P=0.001），ED 时对伴侣排卵的认识更高（P=0.001），GAD-7 评分较低（P=0.016），性欲较低（P=0.005），每月性交次数较少（P=0.001），性满意度评分较低（P=0.027）。多变量分析发现，原发性不育是焦虑的独立危险因素（OR：1.812，95%CI：1.015-3.236）。原发性和继发性不育之间在与 ED、心理障碍和性功能相关的因素上存在一些重叠，但也存在一些不同的因素。
继发性不育男性的 ED 患病率高于原发性不育男性，性生活质量下降。原发性不育是焦虑的独立危险因素。
