Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.
Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo (USP), São Paulo, Brazil.
Eur Arch Psychiatry Clin Neurosci. 2021 Dec;271(8):1579-1586. doi: 10.1007/s00406-021-01248-w. Epub 2021 Mar 10.
Glutamatergic neurotransmission dysfunction and the early involvement of the hippocampus have been proposed to be important aspects of the pathophysiology of schizophrenia. Here, we performed proteomic analysis of hippocampus postmortem samples from schizophrenia patients as well as neural cells-neurons and oligodendrocytes-treated with MK-801, an NMDA receptor antagonist. There were similarities in processes such as oxidative stress and apoptotic process when comparing hippocampus samples with MK-801-treated neurons, and in proteins synthesis when comparing hippocampus samples with MK-801-treated oligodendrocytes. This reveals that studying the effects of glutamatergic dysfunction in different neural cells can contribute to a better understanding of what it is observed in schizophrenia patients' postmortem brains.
谷氨酸能神经传递功能障碍和海马体的早期受累被认为是精神分裂症病理生理学的重要方面。在这里，我们对精神分裂症患者的海马体死后样本以及用 NMDA 受体拮抗剂 MK-801 处理的神经细胞-神经元和少突胶质细胞进行了蛋白质组学分析。当将海马体样本与用 MK-801 处理的神经元进行比较时，在氧化应激和凋亡过程等方面存在相似性，而当将海马体样本与用 MK-801 处理的少突胶质细胞进行比较时，在蛋白质合成方面存在相似性。这表明，研究不同神经细胞中谷氨酸能功能障碍的影响有助于更好地理解在精神分裂症患者死后大脑中观察到的情况。
