Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Int Wound J. 2021 Dec;18(6):763-776. doi: 10.1111/iwj.13577. Epub 2021 Mar 9.
Our purpose was to perform a meta-analysis to evaluate the effect of Low-level laser therapy (LLLT) on diabetic foot ulcers (DFUs). The PubMed, Cochrane, Embase, Web of Science, Chinese BioMedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), VIP and Wanfang databases were searched systematically up to August 27, 2020. Studies that met the inclusion criteria were included in the analysis. A total of 13 randomised controlled trials (RCTs) and 413 patients were analysed. Compared with the control group, LLLT significantly increased the complete healing rate (risk ratio [RR] = 2.10, 95% confidence interval [CI] 1.56-2.83, P < .00001), reduced the ulcer area (standardised mean difference [SMD] = 3.52, 95% CI 1.65-5.38, P = .0002), and shortened the mean healing time (SMD = -1.40, 95% CI -1.90 to -0.91, P < .00001) of patients with DFUs. The quality of the evidence was very low according to the GRADE system. LLLT is a promising and effective adjuvant treatment to accelerate the healing of DFUs. Further evidence from larger samples and higher quality RCTs is needed to prove the effect of LLLT and to determine the most appropriate parameters for the healing of DFUs.
我们的目的是进行荟萃分析，以评估低水平激光疗法（LLLT）对糖尿病足溃疡（DFUs）的疗效。系统检索了 PubMed、Cochrane、Embase、Web of Science、中国生物医学文献数据库（CBM）、中国知网（CNKI）、维普及万方数据库，截至 2020 年 8 月 27 日。符合纳入标准的研究被纳入分析。共纳入 13 项随机对照试验（RCT）和 413 例患者。与对照组相比，LLLT 显著提高了完全愈合率（风险比[RR] = 2.10，95%置信区间[CI] 1.56-2.83，P<.00001），降低了溃疡面积（标准化均数差[SMD] = 3.52，95%CI 1.65-5.38，P=.0002），并缩短了 DFUs 患者的平均愈合时间（SMD = -1.40，95%CI -1.90 至 -0.91，P<.00001）。根据 GRADE 系统，证据质量非常低。LLLT 是一种有前途且有效的辅助治疗方法，可加速 DFUs 的愈合。需要更多来自更大样本和更高质量 RCT 的证据来证明 LLLT 的疗效，并确定最适合 DFUs 愈合的参数。
