Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, 400010 Chongqing, China.
Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, 400010 Chongqing, China.
Diabetes Res Clin Pract. 2018 Sep;143:215-224. doi: 10.1016/j.diabres.2018.07.014. Epub 2018 Jul 23.
The goal of this systematic review and meta-analysis based on seven Randomized control trials (RCTs) is to examine whether Low-level light therapy (LLLT) is effective at healing diabetic foot ulcer (DFU) and to provide evidence-based recommendations and clinical guidelines for the future clinical treatment of DFUs.
Medline, Embase, Scopus, Cochrane Library, and Web of Science databases were searched for studies published up to June 30, 2017, without language or data restrictions. RCTs that investigated the use of LLLT for DFU treatment were included. Standard methods of meta-analysis were performed to evaluate outcomes of LLLT on the healing of DFU.
Seven RCTs involving 194 participants were eligible for this systematic review and meta-analysis. The results of meta-analysis showed that LLLT has emerged as a potential noninvasive treatment for DFUs, as LLLT was found to effectively reduce the ulcer area [weighted mean difference (WMD) 34.18, 95% confidence intervals (CI) 19.38-48.99, P < 0.00001], improve the complete healing rate [odds ratio (OR) 6.72, 95% CI 1.99-22.64, P = 0.002]. Qualitative analysis of the included RCTs found that LLLT also played a role in the treatment of DFUs through promoting rapid granulation formation and shortening ulcer closure time, as well as alleviating foot ulcer pain. None of the treatment-related adverse event was reported.
LLLT was recognized as a potential method in the comprehensive treatment of DFUs. Further well designed and high-quality studies are required to confirm the role of LLLT in the management of DFUs.
本系统评价和荟萃分析基于 7 项随机对照试验（RCT），旨在研究低水平光疗法（LLLT）是否能有效治疗糖尿病足溃疡（DFU），并为未来 DFU 的临床治疗提供循证建议和临床指南。
检索了 Medline、Embase、Scopus、Cochrane 图书馆和 Web of Science 数据库，检索时间截至 2017 年 6 月 30 日，无语言或数据限制。纳入了研究 LLLT 治疗 DFU 的 RCT。采用荟萃分析标准方法评估 LLLT 对 DFU 愈合的疗效。
共有 7 项 RCT 符合纳入标准，共纳入 194 名患者。荟萃分析结果表明，LLLT 作为一种潜在的非侵入性治疗 DFU 的方法，已显示出有效性，可有效缩小溃疡面积[加权均数差（WMD）34.18，95%置信区间（CI）19.38-48.99，P<0.00001]，提高完全愈合率[比值比（OR）6.72，95%CI 1.99-22.64，P=0.002]。对纳入 RCT 的定性分析发现，LLLT 通过促进快速肉芽形成和缩短溃疡愈合时间以及缓解足部溃疡疼痛，在 DFU 的治疗中也发挥了作用。未报告与治疗相关的不良事件。
LLLT 被认为是 DFU 综合治疗的一种有潜力的方法。需要进一步设计良好且高质量的研究来证实 LLLT 在 DFU 管理中的作用。
