Department of Internal Medicine, College of Integrated Chinese and Western Medicine of Hunan University of Chinese Medicine, 300 Xueshi Road, Changsha, 410007, Hunan, People's Republic of China.
Hunan Key Laboratory of TCM Prescription and Syndromes Translational Medicine, Hunan University of Chinese Medicine, Changsha, 410208, People's Republic of China.
Cell Commun Signal. 2021 Mar 22;19(1):37. doi: 10.1186/s12964-021-00721-2.
The circadian clock is an endogenous timekeeper system that controls and optimizes biological processes, which are consistent with a master circadian clock and peripheral clocks and are controlled by various genes. Notably, the disruption of circadian clock genes has been identified to affect a wide range of ailments, including cancers. The cancer-immunity cycle is composed of seven major steps, namely cancer cell antigen release and presentation, priming and activation of effector immunity cells, trafficking, and infiltration of immunity to tumors, and elimination of cancer cells. Existing evidence indicates that the circadian clock functions as a gate that govern many aspects of the cancer-immunity cycle. In this review, we highlight the importance of the circadian clock during tumorigenesis, and discuss the potential role of the circadian clock in the cancer-immunity cycle. A comprehensive understanding of the regulatory function of the circadian clock in the cancer-immunity cycle holds promise in developing new strategies for the treatment of cancer. Video Abstract.
生物钟是一种内源性的计时系统，它控制和优化生物过程，这些过程与主生物钟和外周钟同步，并受各种基因的控制。值得注意的是，生物钟基因的破坏已被确定会影响广泛的疾病，包括癌症。癌症-免疫循环由七个主要步骤组成，即癌细胞抗原的释放和呈递、效应免疫细胞的启动和激活、免疫细胞的运输和浸润肿瘤，并消除癌细胞。现有证据表明，生物钟作为一个门控，控制着癌症-免疫循环的许多方面。在这篇综述中，我们强调了生物钟在肿瘤发生过程中的重要性，并讨论了生物钟在癌症-免疫循环中的潜在作用。全面了解生物钟在癌症-免疫循环中的调节功能有望为癌症治疗开发新策略。视频摘要。
Zotero 插件
