用于累积铅暴露的 DNA 甲基化生物标志物与帕金森病有关。
DNA methylation biomarker for cumulative lead exposure is associated with Parkinson's disease.
机构信息
Department of Neurology, David Geffen School of Medicine, 73-320B CHS Campus, Los Angeles, CA, 177220, USA.
Department of Human Genetics, David Geffen School of Medicine, Los Angeles, CA, USA.
出版信息
Clin Epigenetics. 2021 Mar 22;13(1):59. doi: 10.1186/s13148-021-01051-3.
Abstract
Lead, a known neurotoxicant, has previously received attention in Parkinson's disease (PD) research, but epidemiologic studies have been limited in sample size and findings are equivocal. We generated two methylation-based biomarkers for cumulative tibia and patella bone-measured lead exposure in 1528 PD patients and 1169 controls. PD status was associated with increased levels of the DNAm biomarker for tibia-lead levels. We estimated a meta-OR for PD of 1.89 per unit DNAm tibia-lead increase (95% CI 1.59, 2.24; p = 8.1E-13). The current study supports the notion that chronic and long-term lead exposure tracked via DNAm may contribute to PD pathogenesis.
摘要
铅是一种已知的神经毒物，此前一直是帕金森病 (PD) 研究的焦点，但由于样本量有限，流行病学研究的结果存在争议。我们在 1528 名 PD 患者和 1169 名对照中生成了两个基于甲基化的生物标志物，用于累积测量的胫骨和髌骨的铅暴露。PD 状态与 DNAm 生物标志物的水平增加有关，该标志物用于测量胫骨铅水平。我们估计 PD 的 Meta-OR 为每单位 DNAm 胫骨铅增加 1.89（95%CI 1.59，2.24；p = 8.1E-13）。本研究支持了这样一种观点，即通过 DNAm 追踪的慢性和长期铅暴露可能导致 PD 的发病机制。
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