University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France.
Univ Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail) - UMR_S 1085, Rennes, France.
Nat Neurosci. 2024 May;27(5):812-821. doi: 10.1038/s41593-024-01627-1. Epub 2024 Apr 29.
Over the past few decades, numerous environmental chemicals from solvents to pesticides have been suggested to be involved in the development and progression of neurodegenerative diseases. Most of the evidence has accumulated from occupational or cohort studies in humans or laboratory research in animal models, with a range of chemicals being implicated. What has been missing is a systematic approach analogous to genome-wide association studies, which have identified dozens of genes involved in Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases. Fortunately, it is now possible to study hundreds to thousands of chemical features under the exposome framework. This Perspective explores how advances in mass spectrometry make it possible to generate exposomic data to complement genomic data and thereby better understand neurodegenerative diseases.
在过去几十年中，许多环境化学物质，从溶剂到杀虫剂，都被认为与神经退行性疾病的发展和进展有关。大多数证据来自于人类的职业或队列研究或动物模型的实验室研究，涉及多种化学物质。所缺少的是一种类似于全基因组关联研究的系统方法，全基因组关联研究已经确定了数十个与阿尔茨海默病、帕金森病和其他神经退行性疾病有关的基因。幸运的是，现在有可能在暴露组框架下研究数百到数千种化学特征。本观点探讨了质谱技术的进步如何使生成暴露组数据成为可能，以补充基因组数据，从而更好地理解神经退行性疾病。
