Department of Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
J Invest Dermatol. 2021 Apr;141(4):718-721. doi: 10.1016/j.jid.2020.10.005.
Several epidemiologic studies and GWASs have implicated genetic factors in the pathogenesis of vitiligo. The report by Kim et al. (2020) describes a prospective cohort study from Korea that has the greatest statistical power to date in addressing the epidemiology of vitiligo inheritance. The authors reported the incidence risk ratios in individuals whose first-degree relatives or spouses are affected, providing clear evidence that both genetic and nongenetic factors influence the pathogenesis of vitiligo.
几项流行病学研究和全基因组关联研究表明，遗传因素在白癜风的发病机制中起作用。Kim 等人（2020 年）的报告描述了一项来自韩国的前瞻性队列研究，该研究在迄今为止解决白癜风遗传流行病学方面具有最大的统计学效力。作者报告了一级亲属或配偶患病的个体的发病风险比，这提供了明确的证据，表明遗传和非遗传因素都影响白癜风的发病机制。
