Department of Biochemistry, Basic Medical Science Block-II, Panjab University, Chandigarh, 160014, India.
Department of Biochemistry, Basic Medical Science Block-II, Panjab University, Chandigarh, 160014, India.
Neurochem Int. 2021 Jun;146:105023. doi: 10.1016/j.neuint.2021.105023. Epub 2021 Mar 20.
Azadirachta indica or Neem has been extensively used in the Indian traditional medical system because of its broad range of medicinal properties. Neem contains many chemically diverse and structurally complex phytochemicals such as limonoids, flavonoids, phenols, catechins, gallic acid, polyphenols, nimbins. These phytochemicals possess vast array of therapeutic activities that include anti-feedant, anti-viral, anti-malarial, anti-bacterial, anti-cancer properties. In recent years, many phytochemicals from Neem have been shown to be beneficial against various neurological disorders like Alzheimer's and Parkinson's disease, mood disorders, ischemic-reperfusion injury. The neuroprotective effects of the phytochemicals from Neem are primarily mediated by their anti-oxidant, anti-inflammatory and anti-apoptotic activities along with their ability to modulate signaling pathways. However, extensive studies are still required to fully understand the molecular mechanisms involved in neuropotective effects of phytochemicals from Neem. This review is an attempt to cover the neuroprotective properties of various phytochemicals from Neem along with their mechanism of action so that the potential of the compounds could be realized to reduce the burden of neurodegenerative diseases.
印度楝或尼姆已被广泛应用于印度传统医学体系，因为它具有广泛的药用特性。尼姆含有许多化学性质多样且结构复杂的植物化学物质，如 limonoids、类黄酮、酚类、儿茶素、没食子酸、多酚、nimbins。这些植物化学物质具有广泛的治疗作用，包括抗饲料、抗病毒、抗疟疾、抗细菌、抗癌特性。近年来，许多来自印度楝的植物化学物质已被证明对各种神经紊乱疾病如阿尔茨海默病和帕金森病、情绪障碍、缺血再灌注损伤具有益处。印度楝植物化学物质的神经保护作用主要是通过其抗氧化、抗炎和抗细胞凋亡作用以及调节信号通路的能力来介导的。然而，仍需要广泛的研究来充分了解印度楝植物化学物质的神经保护作用涉及的分子机制。本文综述了各种来自印度楝的植物化学物质的神经保护特性及其作用机制，以便能够认识到这些化合物的潜力，从而减轻神经退行性疾病的负担。
