Zunita Megawati, Adityawarman Dendy, Iskandar Eveline, Ramadhan Rahadian Rizky
Chemical Engineering Department, Faculty of Industrial Technology, Institut Teknologi Bandung Jalan Ganesha 10 Bandung West Java 40132 Indonesia
RSC Adv. 2025 Jul 22;15(32):26104-26137. doi: 10.1039/d5ra02597d. eCollection 2025 Jul 21.
Barium sulphate nanoparticles (BaSO NPs) have garnered considerable attention owing to their distinctive physicochemical characteristics and varied uses in the polymer industry and medicine. Their synthesis by the bottom-up precipitation process is significantly affected by capping agents, which are crucial for regulating shape and size. BaSO nanoparticles exhibit significant potential in medical imaging, reinforcing of bone cement, and administration of cancer therapeutics, while simultaneously improving the tensile strength, thermal stability, and impact resistance of polymers. This review paper examines the influence of diverse capping agents, including polymers, surfactants, and organic compounds, on the shape and size modulation of nanoparticles. It also analyses reactor modifications, such as rotating packed beds, T-mixers, membrane reactors, and spinning disc reactors, to enhance size distribution. This review also emphasises the prospective applications of BaSO nanoparticles in medical imaging, targeted medication administration, energy storage, and composite materials. Green synthesis techniques and ionic liquid-assisted methods are examined to enhance the sustainable manufacture of BaSO nanoparticles.
硫酸钡纳米颗粒（BaSO NPs）因其独特的物理化学特性以及在聚合物工业和医学中的多种用途而备受关注。通过自下而上沉淀法合成它们时，封端剂会对其产生显著影响，封端剂对于调节颗粒形状和尺寸至关重要。硫酸钡纳米颗粒在医学成像、骨水泥增强和癌症治疗给药方面展现出巨大潜力，同时还能提高聚合物的拉伸强度、热稳定性和抗冲击性。本文综述探讨了包括聚合物、表面活性剂和有机化合物在内的多种封端剂对纳米颗粒形状和尺寸调节的影响。还分析了反应器的改进措施，如旋转填充床、T型混合器、膜反应器和旋转盘式反应器，以改善粒径分布。本综述还强调了硫酸钡纳米颗粒在医学成像、靶向给药、能量存储和复合材料方面的潜在应用。研究了绿色合成技术和离子液体辅助方法，以促进硫酸钡纳米颗粒的可持续制造。
