一种同属筛选方法揭示了新型效应子以及研究发病机制的新可能性。
A Same-Genus Screening Approach Reveals Novel Effectors and New Possibilities for Investigating Pathogenesis.
作者信息
Ryan John D, Nelson David E
机构信息
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
出版信息
J Bacteriol. 2021 Jun 1;203(11). doi: 10.1128/JB.00157-21. Epub 2021 Mar 22.
Abstract
are obligate intracellular pathogens that rely on secreted effector proteins to establish their intracellular niche. In this issue of the , Yanatori describe a screen for effectors, performed in , which identified several new proteins that are translocated during infection (Yanatori, Miura et al. 2021). More broadly, they demonstrate how new genetic approaches in can be used to characterize the virulence factors of other species.
摘要
是专性细胞内病原体，依赖分泌的效应蛋白来建立其细胞内生态位。在本期《 》中，柳取等描述了在 中进行的针对 效应蛋白的筛选，该筛选鉴定出了几种在感染过程中易位的新蛋白（柳取、三浦等，2021年）。更广泛地说，他们展示了 中的新遗传方法如何可用于表征其他 物种的毒力因子。
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