Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110;
Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110.
Proc Natl Acad Sci U S A. 2021 Mar 30;118(13). doi: 10.1073/pnas.2019128118.
Whole-brain resting-state functional MRI (rs-fMRI) during 2 wk of upper-limb casting revealed that disused motor regions became more strongly connected to the cingulo-opercular network (CON), an executive control network that includes regions of the dorsal anterior cingulate cortex (dACC) and insula. Disuse-driven increases in functional connectivity (FC) were specific to the CON and somatomotor networks and did not involve any other networks, such as the salience, frontoparietal, or default mode networks. Censoring and modeling analyses showed that FC increases during casting were mediated by large, spontaneous activity pulses that appeared in the disused motor regions and CON control regions. During limb constraint, disused motor circuits appear to enter a standby mode characterized by spontaneous activity pulses and strengthened connectivity to CON executive control regions.
在为期 2 周的上肢固定期间进行的全脑静息态功能磁共振成像 (rs-fMRI) 研究表明，失用的运动区域与扣带前回-脑岛网络 (CON) （包括背侧前扣带皮层 (dACC) 和脑岛的执行控制网络）之间的连接变得更强。功能连接 (FC) 的失用驱动增加是 CON 和躯体运动网络特有的，不涉及任何其他网络，如突显网络、额顶叶网络或默认模式网络。屏蔽和建模分析表明，在 Casting 期间，FC 的增加是由在失用运动区域和 CON 控制区域中出现的大的自发活动脉冲介导的。在肢体约束期间，失用的运动回路似乎进入以自发活动脉冲为特征的备用模式，并增强与 CON 执行控制区域的连接。
