Higgins P D, Adams W M, Dubielzig R R
Department of Human Oncology, University of Wisconsin, Madison 53792.
Radiat Res. 1988 May;114(2):225-30.
The response of normal porcine fat and muscle to graduated doses of hyperthermia provided by an annularly focused acoustic source was measured. Temperatures and exposure times were varied between 43 degrees C (20-90 min), 45 and 47 degrees C (20-60 min), and 49 degrees C (20 min). Response, based on histologic grading of the treated sites 30 days after exposure, was found to correlate well when mapped against several methods of estimating thermal energy deposition. The threshold for damage production was at or near 43 degrees C. For a given temperature, a nearly exponential increase in relative tissue damage as a function of increased exposure time was found. A twofold increase in tissue damage was produced in fat relative to muscle at any given thermal dose.
测量了正常猪脂肪和肌肉对环形聚焦声源提供的不同剂量热疗的反应。温度和暴露时间在43℃（20 - 90分钟）、45℃和47℃（20 - 60分钟）以及49℃（20分钟）之间变化。基于暴露后30天对治疗部位的组织学分级得出的反应，在与几种估计热能沉积的方法进行对比时，发现相关性良好。产生损伤的阈值在43℃或接近43℃。对于给定温度，发现相对组织损伤随暴露时间增加几乎呈指数增加。在任何给定热剂量下，脂肪中的组织损伤相对于肌肉增加了两倍。
