Meshorer A, Prionas S D, Fajardo L F, Meyer J L, Hahn G M, Martinez A A
Arch Pathol Lab Med. 1983 Jun;107(6):328-34.
The alterations produced by radiofrequency-induced hyperthermia of 42 to 48 degrees C for 30 minutes were studied in the subcutaneous adipose tissue and skeletal muscle of swine. Acute lesions (18 to 24 hours) included edema, hemorrhage, necrosis (predominantly of myocytes) and granulocytic exudate in fat or muscle. The most important chronic lesion (28 to 31 days) was fibrosis replacing either tissue. There was a histiolymphocytic exudate with foreign-body giant cells around large lipid vacuoles. Muscle necrosis persisted and there was variable myocyte regeneration. Several specimens showed deep necrosis and abscesses. A grading system was developed to quantitate independently acute and chronic damage in each tissue. Acute lesions were usually less severe and extensive than chronic ones, without obvious dose response. Chronic lesions showed clearly a dose response, which began at 43 degrees C and increased with temperature. The latter appear to be reliable indicators of hyperthermic damage in deep soft tissues.
研究了在猪的皮下脂肪组织和骨骼肌中，通过射频诱导产生42至48摄氏度的热疗持续30分钟所造成的改变。急性损伤（18至24小时）包括水肿、出血、坏死（主要是肌细胞坏死）以及脂肪或肌肉中的粒细胞渗出。最重要的慢性损伤（28至31天）是纤维组织取代了上述两种组织。在大的脂质空泡周围有组织淋巴细胞渗出以及异物巨细胞。肌肉坏死持续存在，并且有不同程度的肌细胞再生。一些标本显示有深部坏死和脓肿形成。开发了一种分级系统，以独立量化每个组织中的急性和慢性损伤。急性损伤通常不如慢性损伤严重和广泛，且没有明显的剂量反应。慢性损伤明显呈现剂量反应，从43摄氏度开始，并随温度升高而增加。后者似乎是深部软组织热损伤的可靠指标。
