Department of Neurosciences, 8784University of California, San Diego, CA, USA.
Rady Children's Hospital, San Diego, CA, USA.
J Child Neurol. 2021 Aug;36(9):735-742. doi: 10.1177/08830738211000507. Epub 2021 Mar 23.
A retrospective cohort analysis was performed on 79 consecutive patients between 6 months and 5 years admitted to a tertiary hospital with a diagnosis of complex febrile seizures requiring mechanical ventilation from 2011 to 2017 to determine the utility of infectious and neurologic diagnostics. Intubation was used as a proxy for severity of illness. The overall intensive care unit stay was short (95% intubated <24 hours, 88% admitted <3 days). No life-threatening infections were identified, and none required surgical interventions. Electroencephalogram (EEG) was obtained on 43%, 26% of which were abnormal. Sixty-six percent of patients were discharged on rescue benzodiazepine and 20% with maintenance antiseizure medications. Duration of follow-up averaged 4 years (range 1 month to 9 years); 8 patients (10%) were subsequently diagnosed with epilepsy. Our findings suggest that extensive diagnostic evaluations may not be necessary for children with complex febrile seizures requiring mechanical ventilation although the role of EEG is less understood.
对 2011 年至 2017 年间因复杂热性惊厥入住三级医院并需要机械通气的 79 例连续患者进行回顾性队列分析，以确定感染和神经诊断的效用。插管被用作疾病严重程度的替代指标。总体重症监护病房住院时间短（95%插管<24 小时，88%入院<3 天）。未发现危及生命的感染，也无需手术干预。43%的患者进行了脑电图（EEG）检查，其中 26%异常。66%的患者出院时使用了抢救性苯二氮䓬类药物，20%的患者使用了维持性抗癫痫药物。平均随访时间为 4 年（范围 1 个月至 9 年）；8 名患者（10%）随后被诊断为癫痫。我们的研究结果表明，对于需要机械通气的复杂热性惊厥儿童，广泛的诊断评估可能不是必需的，尽管 EEG 的作用还不太清楚。
