12310Penn State College of Medicine, Hershey, PA, USA.
Pediatrics, Department of Pediatrics, 509393Penn State Hershey Children's Hospital, Hershey, PA, USA.
J Child Neurol. 2022 Apr;37(5):410-415. doi: 10.1177/08830738221086863. Epub 2022 Mar 14.
BACKGROUND/OBJECTIVES: Infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be associated with febrile seizures, but the overall frequency and outcomes are unknown. The objectives of this study are to (1) determine the frequency of pediatric subjects diagnosed with febrile seizures and COVID-19, (2) evaluate patient characteristics, and (3) describe the treatments (medications and need for invasive mechanical ventilation) applied.
This was a retrospective study utilizing TriNetX electronic health record data. We included subjects ranging from 0 to 5 years of age with a diagnosis of febrile seizures (R56.00, R56.01) and COVID-19 (U07.1). We extracted the following data: age, race, ethnicity, diagnostic codes, medications, laboratory results, and procedures.
During this study period, 8854 pediatric subjects aged 0-5 years were diagnosed with COVID-19 among 34 health care organizations and 44 (0.5%) were also diagnosed with febrile seizures (simple, 30 [68.2%]; complex, 14 [31.8%]). The median age was 1.5 years (1, 2), there were no reported epilepsy diagnoses, and a proportion required hospitalization (11; 25.0%) and critical care services (4; 9.1%).
COVID-19 infections in children can be associated with febrile seizures. In our study, 0.5% of COVID-19 subjects were diagnosed with febrile seizures and approximately 9% of subjects were reported to require critical care services. Febrile seizures, although serious, are not a commonly diagnosed neurologic manifestation of COVID-19.
背景/目的：感染严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）可能与热性惊厥有关，但总体频率和结局尚不清楚。本研究的目的是：（1）确定诊断为热性惊厥和 COVID-19 的儿科患者的频率，（2）评估患者特征，（3）描述应用的治疗方法（药物和是否需要有创机械通气）。
这是一项使用 TriNetX 电子病历数据的回顾性研究。我们纳入了年龄在 0 至 5 岁之间、诊断为热性惊厥（R56.00、R56.01）和 COVID-19（U07.1）的患者。我们提取了以下数据：年龄、种族、民族、诊断代码、药物、实验室结果和程序。
在本研究期间，在 34 家医疗机构中，8854 名 0-5 岁儿科患者被诊断为 COVID-19，其中 44 名（0.5%）患者还被诊断为热性惊厥（单纯性 30 例[68.2%]；复杂性 14 例[31.8%]）。中位年龄为 1.5 岁（1，2），无癫痫诊断报告，需要住院治疗的比例为 11 例（25.0%）和重症监护服务的比例为 4 例（9.1%）。
儿童 COVID-19 感染可能与热性惊厥有关。在我们的研究中，0.5%的 COVID-19 患者被诊断为热性惊厥，约 9%的患者需要重症监护服务。热性惊厥虽然严重，但不是 COVID-19 的常见神经系统表现。
