Université de Paris, Centre National de la Recherche Scientifique, Institut Jacques Monod, Paris, France.
J Cell Biol. 2021 Apr 5;220(4). doi: 10.1083/jcb.202102020.
The turnover of actin filament networks in cells has long been considered to reflect the treadmilling behavior of pure actin filaments in vitro, where only the pointed ends depolymerize. Newly discovered molecular mechanisms challenge this notion, as they provide evidence of situations in which growing and depolymerizing barbed ends coexist.
细胞中肌动蛋白丝网络的周转率长期以来一直被认为反映了体外纯肌动蛋白丝的 treadmilling 行为，其中只有尖端解聚。新发现的分子机制挑战了这一观点，因为它们提供了证据表明生长和解聚的棘状末端共存的情况。
