Seegenschmiedt M H, Brady L W, Rossmeissl G
Department of Radiation Oncology and Nuclear Medicine, Hahnemann University, Philadelphia, PA 19102.
Recent Results Cancer Res. 1988;107:147-51. doi: 10.1007/978-3-642-83260-4_21.
From January 1986 to January 1987 at Hahnemann University Hospital, Philadelphia, 13 patients were treated with combined external hyperthermia and radiation therapy to extensive chest wall recurrences from carcinoma of the breast. A total of 145 hyperthermia sessions for 27 different hyperthermia fields were analyzed in this study. Mixed photon (10 MV) or electron beam (6-15 MeV) radiation therapy (16-50.5 Gy, two to five weekly fractions of 1.5-2.0 Gy) was given followed within 30 min by external 915-MHz microwave hyperthermia (two weekly fractions for 60 min at 41-44 degrees C). Temperature recordings were made at up to 24 points in the center and periphery and at junctions of fields. The thermal dose concept of Sapareto (T43 Eq) was used to evaluate the relationship between maximum or minimum temperature (TMAX/TMIN) and rates of complication and of CR for each treatment field. Our results indicate that total or mean TMAX43 Eq per hyperthermia treatment field is related to complication rate, whereas total or mean TMIN43 Eq is related to CR rate. Also, higher radiation dose and smaller involved tumor area are related to higher CR rates. At 1 month follow-up 13/27 (48%) fields showed CR. At 3 months, four more CRs were noted, yielding 17/23 (74%) CR.
1986年1月至1987年1月期间，在费城哈内曼大学医院，13例乳腺癌胸壁广泛复发患者接受了体外热疗与放射治疗相结合的治疗。本研究共分析了27个不同热疗区域的145次热疗疗程。先给予混合光子（10兆伏）或电子束（6 - 15兆电子伏）放射治疗（16 - 50.5戈瑞，每周2至5次，每次1.5 - 2.0戈瑞），然后在30分钟内进行915兆赫的体外微波热疗（每周2次，每次60分钟，温度41 - 44摄氏度）。在热疗区域的中心、周边以及交界处最多24个点进行温度记录。采用萨帕雷托的热剂量概念（T43公式）来评估每个治疗区域的最高或最低温度（TMAX/TMIN）与并发症发生率和完全缓解率之间的关系。我们的结果表明，每个热疗区域的总TMAX43公式或平均TMAX43公式与并发症发生率相关，而总TMIN43公式或平均TMIN43公式与完全缓解率相关。此外，较高的放射剂量和较小的受累肿瘤面积与较高的完全缓解率相关。在1个月的随访中，27个区域中有13个（48%）显示完全缓解。在3个月时，又有4个区域达到完全缓解，完全缓解率为17/23（74%）。
