钙盐性质对血清钙、磷、降钙素、生长激素和生长调节素C的影响

Influence of the nature of calcium salts on serum calcium, phosphorus, calcitonin, growth hormone, and somatomedin C.

作者信息

Reginster J Y, Denis D, Albert A, Gaspar S, Heynen G, Deroisy R, Franchimont P

机构信息

Dept. of Rheumatology and Physical Medicine, University of Liège, Belgium.

出版信息

Res Exp Med (Berl). 1988;188(2):131-7. doi: 10.1007/BF01852269.

DOI:10.1007/BF01852269

PMID:3375576

Abstract

Twenty healthy males were randomly divided into three groups. Each subject received either 405 mg elemental calcium (Ca) as a salt linked to an amino acid precursor, 405 mg CaC12 or 1000 mg Ca as Ca gluconolactate and carbonate. In all three cases, Ca intake led to an increase of serum Ca and TCT production and a decrease of PTH liberation. However, when Ca is linked to the amino acid precursor, an elective stimulation of growth hormone (GH) and somatomedin C (SmC) occurs. Due to the nature of its amino acid precursor, this salt seems to stimulate GH and SmC liberation through hypophysis. This could be a major pathway in decoupling of the sequence resorption-formation and therapy of metabolic bone diseases.

摘要

20名健康男性被随机分为三组。每位受试者分别接受405毫克与氨基酸前体结合的盐形式的元素钙（Ca）、405毫克氯化钙或1000毫克葡萄糖酸钙和碳酸钙形式的钙。在所有三种情况下，钙的摄入均导致血清钙和降钙素（TCT）分泌增加，甲状旁腺激素（PTH）释放减少。然而，当钙与氨基酸前体结合时，会选择性地刺激生长激素（GH）和生长调节素C（SmC）的分泌。由于其氨基酸前体的性质，这种盐似乎通过垂体刺激GH和SmC的释放。这可能是代谢性骨病吸收-形成序列解耦和治疗的主要途径。