Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
Mol Cell Biochem. 2021 Aug;476(8):2943-2949. doi: 10.1007/s11010-021-04123-3. Epub 2021 Mar 23.
Since the lack of certainty in identifying polycystic ovary syndrome (PCOS) demonstrates confusion regarding the disorder's pathophysiology and its therapeutic approaches, systematic screening of women under diagnostic guidelines of the NIH reported that about 4-10 percent of reproductive women aged 20-44 years suffer from PCOS. Not all females with PCOS-defining biochemical and clinical characteristics and about 22% of PCOS women have no symptoms. PCOS is a heterogeneous phenotypic and clinical condition, combined with metabolic implications. The root cause of PCOS is the major issue of IR or irregular androgen secretion and constant effort is being made in identifying the dynamic pathogenic network underlying the syndrome. Regardless of PCOS initiating cause, IR therapy and hyperinsulinemia can restore metabolic and hormonal homeostasis, and minimize ovarian dysfunction. Thus, the impact of insulin on ovaries in hyperinsulinemic individuals can account for many of the PCOS characteristics and is important for developing treatment strategies. Therefore, our primary aim is to investigate the proper understanding of endocrine disruption during PCOS and secondary to the therapeutic potential of inositol in reestablishing the equilibrium of ovarian dysfunction, anovulation, and eventually infertility.
由于多囊卵巢综合征 (PCOS) 的诊断存在不确定性，表明人们对该疾病的病理生理学及其治疗方法存在混淆，因此根据美国国立卫生研究院 (NIH) 的诊断标准对女性进行系统筛查后发现，约有 4-10%的 20-44 岁育龄女性患有 PCOS。并非所有具有 PCOS 定义的生化和临床特征的女性都有症状，约 22%的 PCOS 女性无症状。PCOS 是一种具有代谢影响的异质性表型和临床病症。PCOS 的根本原因是胰岛素抵抗 (IR) 或不规律的雄激素分泌，目前正在努力确定该综合征潜在的动态致病网络。无论 PCOS 的起始原因如何，IR 治疗和高胰岛素血症都可以恢复代谢和激素平衡，并最大程度地减少卵巢功能障碍。因此，胰岛素对高胰岛素血症个体卵巢的影响可以解释 PCOS 的许多特征，这对于制定治疗策略非常重要。因此，我们的主要目标是研究 PCOS 期间内分泌失调的正确理解，以及肌醇在重新建立卵巢功能障碍、无排卵以及最终不孕的平衡方面的治疗潜力。
