穿心莲内酯及其衍生物是用于胃肠保护的有效化合物：综述

Andrographolide and its derivatives are effective compounds for gastrointestinal protection: a review.

作者信息

Wang D-W, Xiang Y-J, Wei Z-L, Yao H, Shen T

机构信息

School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

出版信息

Eur Rev Med Pharmacol Sci. 2021 Mar;25(5):2367-2382. doi: 10.26355/eurrev_202103_25276.

DOI:10.26355/eurrev_202103_25276

PMID:33755974

Abstract

OBJECTIVE

Andrographolide and its derivatives have many functions, such as anti-infection, anti-tumor, neuroprotection, and immune regulation. However, the gastrointestinal protective effects, especially gastrointestinal tumors, and inflammation-related diseases of andrographolide and its derivatives have not been well summarized and discussed. In this review, we aimed to summarize and discuss the pharmacological effects and underlying mechanisms of andrographolide and its derivatives in gastrointestinal protection, with a view to revealing more possibilities of andrographolide and its derivatives in gastrointestinal diseases prevention therapy.

MATERIALS AND METHODS

The data in this review are searched and selected from PubMed with the keywords: Andrographolide and Andrographolide derivatives, and relevant data with gastrointestinal protection are extracted and discussed.

RESULTS

Andrographolide and its derivatives have prophylactic and therapeutic effects in gastrointestinal disorders such as GU, gastric cancer, colorectal cancer, and inflammatory bowel disease.

CONCLUSIONS

Andrographolide and its derivatives are effective compounds for gastrointestinal protection.

摘要

目的

穿心莲内酯及其衍生物具有多种功能，如抗感染、抗肿瘤、神经保护和免疫调节等。然而，穿心莲内酯及其衍生物的胃肠道保护作用，尤其是对胃肠道肿瘤及炎症相关疾病的作用，尚未得到充分总结和讨论。在本综述中，我们旨在总结和讨论穿心莲内酯及其衍生物在胃肠道保护方面的药理作用及潜在机制，以期揭示穿心莲内酯及其衍生物在胃肠道疾病防治中的更多可能性。