Deshmukh Rohitas, Jain Aman Kumar, Singh Rajesh, Paul Swarnali Das, Harwansh Ranjit K
Institute of Pharmaceutical Research, GLA University, Mathura, 281406, India.
Department of Pharmacy, Shri Shankaracharya College of Pharmaceutical Sciences, Junwani, Bhilai, 490020, India.
Curr Drug Deliv. 2024;21(5):631-644. doi: 10.2174/1567201820666230203115752.
Cancer is one of the deadliest illnesses of the 21st century. Chemotherapy and radiation therapies both have considerable side effects. Antitumor antibiotics are one of them. Coughs, common colds, fevers, laryngitis, and infectious disorders have all been treated with for centuries. Extracts of effectively treat various ailments, as well as cancer. The most active molecule in is andrographolide a, diterpene, and lactone. and its derivatives have long been used to treat various ailments. Anti-inflammatory and cancerfighting characteristics have been observed in Andrographolide. Andrographolide, a diterpene lactone separated from , has also been shown to have important criticalessential biological protective properties. It has also been suggested that it could be used to treat major human diseases like-rheumatoid like rheumatoid, colitis, and Parkinsons disease. This summary aims to highlight Andrographolide as a promising cancer treatment option. Several databases were searched for andrographolides cytotoxic/anti-cancer effects in pre-clinical and clinical research to serve this purpose. Several studies have shown that Andrographolide is helpful in cancer medication, as detailed in this review.
癌症是21世纪最致命的疾病之一。化疗和放射疗法都有相当大的副作用。抗肿瘤抗生素就是其中之一。几个世纪以来，咳嗽、普通感冒、发烧、喉炎和传染病都用（此处原文缺失相关药物名称）进行治疗。（此处原文缺失相关植物名称）的提取物能有效治疗各种疾病，包括癌症。（此处原文缺失相关植物名称）中最活跃的分子是穿心莲内酯，一种二萜和内酯。（此处原文缺失相关植物名称）及其衍生物长期以来一直用于治疗各种疾病。穿心莲内酯具有抗炎和抗癌特性。从（此处原文缺失相关植物名称）中分离出的二萜内酯穿心莲内酯也被证明具有重要的关键生物保护特性。也有人认为它可用于治疗类风湿性关节炎、结肠炎和帕金森病等重大人类疾病。本综述旨在强调穿心莲内酯作为一种有前景的癌症治疗选择。为了实现这一目的，在几个数据库中搜索了穿心莲内酯在临床前和临床研究中的细胞毒性/抗癌作用。如本综述所述，几项研究表明穿心莲内酯对癌症治疗有帮助。
