Pharmacognosy Group, Department of Pharmaceutical Biosciences, Uppsala University, Biomedical Centre, P.O. Box 591, SE-751 24 Uppsala, Sweden.
School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China.
Nutrients. 2024 Jan 29;16(3):393. doi: 10.3390/nu16030393.
Metabolic disorders, encompassing diabetes mellitus, cardiovascular diseases, gastrointestinal disorders, etc., pose a substantial global health threat, with rising morbidity and mortality rates. Addressing these disorders is crucial, as conventional drugs often come with high costs and adverse effects. This review explores the potential of royal jelly (RJ), a natural bee product rich in bioactive components, as an alternative strategy for managing metabolic diseases. RJ exhibits diverse therapeutic properties, including antimicrobial, estrogen-like, anti-inflammatory, hypotensive, anticancer, and antioxidant effects. This review's focus is on investigating how RJ and its components impact conditions like diabetes mellitus, cardiovascular disease, and gastrointestinal illnesses. Evidence suggests that RJ serves as a complementary treatment for various health issues, notably demonstrating cholesterol- and glucose-lowering effects in diabetic rats. Specific RJ-derived metabolites, such as 10-hydroxy-2-decenoic acid (10-HDA), also known as the "Queen bee acid," show promise in reducing insulin resistance and hyperglycemia. Recent research highlights RJ's role in modulating immune responses, enhancing anti-inflammatory cytokines, and suppressing key inflammatory mediators. Despite these promising findings, further research is needed to comprehensively understand the mechanisms underlying RJ's therapeutic effects.
代谢紊乱包括糖尿病、心血管疾病、胃肠道疾病等，对全球健康构成了重大威胁，其发病率和死亡率不断上升。解决这些疾病至关重要，因为传统药物往往成本高且有副作用。本综述探讨了蜂王浆（RJ）作为一种管理代谢疾病的替代策略的潜力，RJ 是一种富含生物活性成分的天然蜂产品。RJ 具有多种治疗特性，包括抗菌、雌激素样、抗炎、降压、抗癌和抗氧化作用。本综述的重点是研究 RJ 及其成分如何影响糖尿病、心血管疾病和胃肠道疾病等疾病。有证据表明，RJ 可作为各种健康问题的辅助治疗方法，特别是在糖尿病大鼠中表现出降低胆固醇和血糖的作用。特定的 RJ 衍生代谢物，如 10-羟基-2-癸烯酸（10-HDA），也称为“蜂王酸”，在降低胰岛素抵抗和高血糖方面显示出潜力。最近的研究强调了 RJ 在调节免疫反应、增强抗炎细胞因子和抑制关键炎症介质方面的作用。尽管有这些有希望的发现，但仍需要进一步研究来全面了解 RJ 治疗效果的机制。
