OpenBiome, 2067 Massachusetts Ave, Cambridge, MA, 02140, USA.
BMC Res Notes. 2021 Mar 23;14(1):108. doi: 10.1186/s13104-021-05520-z.
Universal stool banks provide stool to physicians for use in treating recurrent Clostridioides difficile infection via fecal microbiota transplantation. Stool donors providing the material are rigorously screened for diseases and disorders with a potential microbiome etiology, and they are likely healthier than the controls in most microbiome datasets. 16S rRNA sequencing was performed on samples from a selection of stool donors at a large stool bank, OpenBiome, to characterize their gut microbial community and to compare samples across different timepoints and sequencing runs.
16S rRNA sequencing was performed on 200 samples derived from 170 unique stool donations from 86 unique donors. Samples were sequenced on 11 different sequencing runs. We are making this data available because rigorously screened, likely very healthy stool donors may be useful for characterizing and understanding microbial community differences across different populations and will help shed light into the how the microbiome community promotes health and disease.
通用粪便库为医生提供粪便，用于通过粪便微生物群移植治疗复发性艰难梭菌感染。提供材料的粪便捐赠者经过严格筛选，以排除具有潜在微生物组病因的疾病和障碍，并且他们可能比大多数微生物组数据集的对照组更健康。对大型粪便库 OpenBiome 中的一组粪便捐赠者的样本进行了 16S rRNA 测序，以描述他们的肠道微生物群落，并比较不同时间点和测序运行的样本。
从 86 位独特供体的 170 个独特粪便捐赠中提取了 200 个样本进行了 16S rRNA 测序。样本在 11 个不同的测序运行中进行了测序。我们提供此数据，是因为经过严格筛选的、可能非常健康的粪便供体可能有助于描述和理解不同人群之间微生物群落的差异，并有助于了解微生物群落如何促进健康和疾病。
