OpenBiome, Cambridge, MA, United States.
Front Cell Infect Microbiol. 2021 Apr 15;11:622949. doi: 10.3389/fcimb.2021.622949. eCollection 2021.
Fecal microbiota transplantation (FMT) is a recommended therapy for recurrent infection and is being investigated as a potential therapy for dozens of microbiota-mediated indications. Stool banks centralize FMT donor screening and FMT material preparation with the goal of expanding access to FMT material while simultaneously improving its safety, quality, and convenience. Although there are published consensuses on donor screening guidelines, there are few reports about the implementation of those guidelines in functioning stool banks.
To help inform consensus standards with data gathered from real-world settings and, in turn, to improve patient care, here we describe the general methodology used in 2018 by OpenBiome, a large stool bank, and its outputs in that year.
In 2018, the stool bank received 7,536 stool donations from 210 donors, a daily average of 20.6 donations, and processed 4,271 of those donations into FMT preparations. The median time a screened and enrolled stool donor actively donated stool was 5.8 months. The median time between the manufacture of an FMT preparation and its shipment to a hospital or physician was 8.9 months. Half of the stool bank's partner hospitals and physicians ordered an average of 0.75 or fewer FMT preparations per month.
Further knowledge sharing should help inform refinements of stool banking guidelines and best practices.
粪便微生物群移植（FMT）是复发性感染的推荐疗法，并且正在作为数十种微生物群介导的适应证的潜在疗法进行研究。粪便库集中了 FMT 供体筛查和 FMT 材料准备，目的是扩大 FMT 材料的获取途径，同时提高其安全性、质量和便利性。尽管有关于供体筛查指南的已发表共识，但关于这些指南在运行中的粪便库中的实施情况的报告很少。
为了帮助用来自真实环境的数据制定共识标准，并进而改善患者护理，我们在此描述了 2018 年大型粪便库 OpenBiome 使用的一般方法及其当年的结果。
2018 年，该粪便库从 210 位供体中收到了 7536 份粪便捐赠，平均每天 20.6 份，其中 4271 份经过处理制成 FMT 制剂。经过筛选并注册的供体积极捐赠粪便的中位时间为 5.8 个月。FMT 制剂生产和运往医院或医生的中位时间为 8.9 个月。该粪便库一半的合作医院和医生平均每月订购的 FMT 制剂少于或等于 0.75 份。
进一步的知识共享应有助于完善粪便库管理指南和最佳实践。
