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洗手对埃塞俄比亚东部农村地区5岁以下儿童腹泻发病率的影响:一项整群随机对照试验

Handwashing effect on diarrheal incidence in children under 5 years old in rural eastern Ethiopia: a cluster randomized controlled trial.

作者信息

Solomon Ephrem Tefera, Gari Sirak Robele, Kloos Helmut, Alemu Bezatu Mengistie

机构信息

Ethiopian Institute of Water Resources, Addis Ababa University, Addis Ababa, Ethiopia.

College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.

出版信息

Trop Med Health. 2021 Mar 23;49(1):26. doi: 10.1186/s41182-021-00315-1.

Abstract

BACKGROUND

Handwashing with soap reduces diarrheal diseases burden considerably. However, the importance of handwashing in homes has received little attention in rural eastern Ethiopia. The effectiveness of handwashing may be reduced by lack of information on when and in what event hands must be washed, the frequency of handwashing, the individual who should wash his/her hands, and the procedure of handwashing. In these areas, indicators of adherence to handwashing are yet to be established. This study aimed at assessing the efficiency of handwashing on reducing diarrheal disease in children under 5 years old in rural kebeles of Dire Dawa, east Ethiopia.

METHODS

Community-based cluster randomized controlled trial was conducted in rural kebeles of Dire Dawa for 4 months starting from October 2018 to January 2019. Selected clusters were randomized in intervention and control arms using draw method and data collectors conducted the baseline survey. Households assigned to the intervention group were given two bars of plain soap on a bi-monthly basis together with information promoting hand hygiene. Control households were allowed to continue their habitual handwashing practices. We compared the diarrheal incidences of the intervention and non-intervention households. Generalized estimation equations using Poisson family and log choice of the link was employed to calculate adjusted incidence rate ratio with its 95% confidence interval.

RESULTS

We recorded a significant lesser diarrheal incidence in the handwashing arm than in the non-intervention arm (6.9 versus 13.8 episodes per 100 person weeks of observation). In all, there was a 41% reduction in diarrheal incidence in the intervention arm in relation to the non-intervention arm.

CONCLUSION

Handwashing with soap complemented with hand hygiene promotion significantly decreased diarrheal episodes in children under 5 years old in rural kebeles of Dire Dawa. We recommend the promotion and adaptation of washing hands using soap at recommended times to be an effective means of reducing childhood diarrhea morbidity in rural populations of Ethiopia towards achieving the Sustainable Development Goal 6.

TRIAL REGISTRATION

PACTR, PACTR201807815961394 . Registered 16 July 2018.

摘要

背景

用肥皂洗手可大幅减轻腹泻疾病负担。然而,在埃塞俄比亚东部农村地区,家庭洗手的重要性几乎未得到关注。关于何时、在何种情况下必须洗手、洗手频率、应该洗手的个人以及洗手程序的信息缺乏,可能会降低洗手的效果。在这些地区,尚未确立洗手依从性的指标。本研究旨在评估在埃塞俄比亚东部迪雷达瓦农村行政区,洗手对降低5岁以下儿童腹泻疾病的效果。

方法

2018年10月至2019年1月,在迪雷达瓦农村行政区开展了为期4个月的基于社区的整群随机对照试验。采用抽签法将选定的整群随机分为干预组和对照组,数据收集员进行基线调查。每两个月给分配到干预组的家庭发放两块普通肥皂,并提供促进手部卫生的信息。对照家庭则允许继续其惯常的洗手做法。我们比较了干预家庭和非干预家庭的腹泻发病率。使用泊松族和对数连接选择的广义估计方程来计算调整后的发病率比及其95%置信区间。

结果

我们记录到,洗手组的腹泻发病率显著低于非干预组(每100人周观察期内分别为6.9次和13.8次发作)。总体而言,干预组的腹泻发病率相对于非干预组降低了41%。

结论

用肥皂洗手并辅以促进手部卫生,可显著减少迪雷达瓦农村行政区5岁以下儿童的腹泻发作次数。我们建议,推广并采用在推荐时间使用肥皂洗手的做法,作为减少埃塞俄比亚农村人口儿童腹泻发病率的有效手段,以实现可持续发展目标6。

试验注册

泛非临床试验注册中心,注册号PACTR201807815961394。于2018年7月16日注册。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69eb/7989202/6f8d78b3b4cf/41182_2021_315_Fig1_HTML.jpg

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