Advocate Children's Hospital, Park Ridge, IL, USA.
Rosaland Franklin University of Medicine and Science, North Chicago, IL, USA.
J Perinatol. 2021 May;41(5):1074-1082. doi: 10.1038/s41372-021-01036-3. Epub 2021 Mar 23.
Estimate the migration of volatile organic compounds (VOCs) which have been identified by the EPA as a public health concern, from the enteral feeding system into human milk.
Unfortified human milk samples were infused through an enteral feeding system with varying duration of infusion, incubator temperature, and pre-infusion tube priming. Purge & Trap analysis and GC/MS were used to identify the VOC profile of milk pre- and post-infusion.
Cyclohexanone and 3,3,5-trimethylcyclohexanone (3,3,5-TMC) accumulated significantly in milk samples post-infusion. Duration of infusion had a significant effect on VOC accumulation (p = 0.001). Accumulation patterns of cyclohexanone and 3,3,5-TMC differed significantly based on milk type (donor vs. mother's own milk).
VOCs, migrate from plastic-based feeding equipment into human milk. Based on these findings, limiting the duration of feeding infusion would reduce VOC exposure derived from enteral feeding in the neonatal intensive care unit.
评估已被 EPA 确定为公共健康关注点的挥发性有机化合物（VOCs）从肠内喂养系统迁移到人乳中的情况。
未强化的母乳样本通过肠内喂养系统以不同的输注持续时间、培养箱温度和预输注管预充进行输注。采用吹扫捕集分析和 GC/MS 来鉴定输注前后牛奶中的 VOC 图谱。
环己酮和 3,3,5-三甲基环己酮（3,3,5-TMC）在输注后明显积累在牛奶样本中。输注持续时间对 VOC 积累有显著影响（p=0.001）。基于母乳类型（捐赠者与母亲自身的母乳），环己酮和 3,3,5-TMC 的积累模式存在显著差异。
VOC 从基于塑料的喂养设备迁移到人乳中。基于这些发现，限制喂养输注的持续时间将减少新生儿重症监护病房肠内喂养中源自 VOC 的暴露。
