Kleinwechter Helmut, Groten Tanja, Schäfer-Graf Ute, Bohlmann Michael K, Ehrhardt Ines, Hein Alexander, Hepp Vanessa, Hollatz-Galluschki Elsa, Kraft Katrina, Kunze Mirjiam, Lihs Angela, Méndez-Martorell Elisa, Oppelt Peter, Ramsauer Babett, Ravnaq-Möllers Tamina, Riebe Bastian, Rohlwink Charlotte, Rübelmann Tanja, Pecks Ulrich
diabetologikum kiel, Diabetesschwerpunktpraxis und Schulungszentrum, Alter Markt 11, 24103 Kiel, Deutschland.
Klinik für Geburtsmedizin, Universitätsklinikum Jena, Jena, Deutschland.
Gynakologe. 2021;54(5):357-365. doi: 10.1007/s00129-021-04784-7. Epub 2021 Mar 18.
From March 3 to October 13, 2020, 27 cases with diabetes comorbidity have been recorded in the CRONOS registry (Covid-19 Related Obstetric and Neonatal Outcome Study in Germany) among 262 registered women with SARS-CoV‑2 infection during their pregnancy. Of those, 21 presented with gestational diabetes, 5 with type 2 diabetes and 1 with type 1 diabetes. About half of the women were asymptomatic and were diagnosed via general screening at hospital admission. The most common symptoms were nasal congestion, cough, tiredness, malaise and changes in smell and taste. The majority of pregnant women showed a mild to moderate course, three women were admitted to the intensive care unit and none required invasive ventilation. In the type 2 diabetes group, there were two cases with late fetal death (37 and 40 weeks of gestation) and one with a malformation, an association with diabetes being most likely. Pregnant women with diabetes mellitus represent a special subgroup; 1 in 10 women in this small cohort required intensive care monitoring due to COVID-19. In addition, this case series underscores the need for unrestricted access to pregnancy care, especially in times of pandemic, for optimal perinatal outcome.
在2020年3月3日至10月13日期间,德国的CRONOS注册研究(Covid-19相关产科和新生儿结局研究)在262名孕期感染SARS-CoV-2的登记女性中记录了27例糖尿病合并症病例。其中,21例为妊娠期糖尿病,5例为2型糖尿病,1例为1型糖尿病。约一半的女性无症状,是在入院时通过常规筛查确诊的。最常见的症状是鼻塞、咳嗽、疲劳、不适以及嗅觉和味觉改变。大多数孕妇病情呈轻至中度,3名女性被收入重症监护病房,无人需要有创通气。在2型糖尿病组中,有2例发生晚期胎儿死亡(妊娠37周和40周),1例有畸形,很可能与糖尿病有关。糖尿病孕妇是一个特殊亚组;在这个小队列中,每10名女性中有1名因COVID-19需要重症监护监测。此外,该病例系列强调了不受限制地获得孕期护理的必要性,尤其是在疫情期间,以实现最佳围产期结局。