慢性肾脏病患者中Klotho和FGF23在心脏瓣膜钙化中的临床价值
The Clinical Value of Klotho and FGF23 in Cardiac Valve Calcification Among Patients with Chronic Kidney Disease.
作者信息
Chen Yan, Chen Yan-Xia, Huang Chong, Duan Zhi-Bing, Xu Cheng-Yun
机构信息
Department of Nephrology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 330006, People's Republic of China.
出版信息
Int J Gen Med. 2021 Mar 15;14:857-866. doi: 10.2147/IJGM.S299197. eCollection 2021.
OBJECTIVE
This study aims to investigate the clinical value of serum Klotho and FGF23 in cardiac valve calcification in patients with chronic kidney disease (CKD).
METHODS
In the present study, 180 patients with CKD, who were admitted to the department of nephrology of our hospital on April 1, 2016 (solstice, 2019), were selected as the main subjects. According to the CKD stage, these patients were divided into three groups: CKD2~3 group, CKD4 group, and CKD5 group. In each group, ultrasound was used to evaluate the cardiac valve calcification, and the independent risk factors for cardiac valve calcification were analyzed by Logistic regression.
RESULTS
The levels of hemoglobin and blood calcium in CKD23 patients were higher than those in CKD4 and CKD5 patients, and the levels of hemoglobin and blood calcium in CKD5 patients were higher than those in CKD4 patients (<0.05). Albumin was lower in CKD23 patients when compared to CKD5 patients while albumin was higher in CKD5 patients when compared to CKD4 patients (<0.05). The serum levels of FGF23 was lower in CKD23 patients when compared to CKD4 and CKD5 patients while the serum levels of FGF23 was lower in CKD4 patients when compared to CKD5 patients (<0.05). The serum levels of Klotho was higher in CKD23 patients, when compared to CKD4 and CKD5 patients, while the serum levels of Klotho was higher in CKD4 patients, when compared to CKD5 patients (<0.05). The logistic regression analysis revealed that GFR, serum creatinine, FGF23 and Klotho were independent risk factors for cardiac valve calcification in patients with CKD.
CONCLUSION
With the decrease of GFR in CKD patients, the serum levels of FGF23 increases, while the serum levels of Klotho decreases. Furthermore, the serum levels of FGF23 and Klotho are affected by various factors, and the levels of FGF23 and Klotho in CKD patients are negatively correlated. GFR, serum creatinine, FGF23 and Klotho are independent risk factors for heart valve calcification in patients with CKD.
目的
本研究旨在探讨血清α-klotho蛋白（Klotho）和成纤维细胞生长因子23（FGF23）在慢性肾脏病（CKD）患者心脏瓣膜钙化中的临床价值。
方法
选取2016年4月1日（至2019年）我院肾内科收治的180例CKD患者作为主要研究对象。根据CKD分期，将这些患者分为三组：CKD2~3组、CKD4组和CKD5组。每组均采用超声评估心脏瓣膜钙化情况，并通过Logistic回归分析心脏瓣膜钙化的独立危险因素。
结果
CKD23期患者的血红蛋白和血钙水平高于CKD4期和CKD5期患者，且CKD5期患者的血红蛋白和血钙水平高于CKD4期患者（P<0.05）。与CKD5期患者相比，CKD23期患者的白蛋白水平较低；与CKD4期患者相比，CKD5期患者的白蛋白水平较高（P<0.05）。与CKD4期和CKD5期患者相比，CKD23期患者的血清FGF23水平较低；与CKD5期患者相比，CKD4期患者的血清FGF23水平较低（P<0.05）。与CKD4期和CKD5期患者相比，CKD23期患者的血清Klotho水平较高；与CKD5期患者相比，CKD4期患者的血清Klotho水平较高（P<0.05）。Logistic回归分析显示，肾小球滤过率（GFR）、血清肌酐、FGF23和Klotho是CKD患者心脏瓣膜钙化的独立危险因素。
结论
随着CKD患者GFR的降低，血清FGF23水平升高，而血清Klotho水平降低。此外，血清FGF23和Klotho水平受多种因素影响，且CKD患者中FGF23和Klotho水平呈负相关。GFR、血清肌酐、FGF23和Klotho是CKD患者心脏瓣膜钙化的独立危险因素。
Zotero 插件