Japan-Thailand Research Collaboration Center on Emerging and Re-emerging Infections, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Department of Infection Control and Prevention, Osaka University Graduate School of Medicine, Suita, Japan.
J Antimicrob Chemother. 2021 May 12;76(6):1448-1454. doi: 10.1093/jac/dkab070.
Carbapenemase-producing Enterobacterales (CPE) are spreading in hospitals, environment and retail foods in Yangon, Myanmar.
To investigate whether CPE colonize healthy individuals living in Yangon and whether clinical-related strains are spreading in the community.
CPE was isolated from faecal samples obtained from healthy Japanese residents of Yangon with no history of hospitalization. Isolates were subjected to WGS using short- and long-read sequencers and compared with those previously isolated in Yangon.
Six Escherichia coli strains harbouring blaNDM-1 or blaNDM-5 belonging to five different STs-ST10, ST38, ST48, ST410 and ST8453-were isolated from 69 volunteers. The ST38 isolates were related to those previously isolated from retail food in Yangon. The ST410 and ST8453 isolates were highly related to previous Yangon isolates including those of clinical and food origins.
The analysis suggested the acquisition of blaNDM-positive E. coli, which are disseminating in a clinical setting and through retail foods, by healthy residents in Yangon.
产碳青霉烯酶肠杆菌科（CPE）在缅甸仰光的医院、环境和零售食品中传播。
调查 CPE 是否定植于仰光的健康个体，以及临床相关菌株是否在社区中传播。
从无住院史的仰光日本常住健康居民的粪便样本中分离出 CPE。使用短读和长读测序仪对分离株进行 WGS，并与之前在仰光分离的菌株进行比较。
从 69 名志愿者中分离出 6 株携带 blaNDM-1 或 blaNDM-5 的大肠杆菌，属于 5 种不同 ST-ST10、ST38、ST48、ST410 和 ST8453。ST38 分离株与之前从仰光零售食品中分离到的菌株有关。ST410 和 ST8453 分离株与之前仰光的分离株高度相关，包括临床和食品来源的分离株。
分析表明，仰光的健康居民获得了blaNDM 阳性大肠杆菌，这些菌株在临床环境和零售食品中传播。
