Department of Iranian Traditional Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, 14166, Iran.
Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, 14194, Iran.
Chin J Integr Med. 2021 Apr;27(4):313-320. doi: 10.1007/s11655-021-3332-7. Epub 2021 Mar 24.
The human immune system represents a dynamic multiscale system with high complexity in biology. Humoral immunity, as the main branch of adaptive immunity, is characterized by differentiated stages of the B lymphocytes, producing the final product of antibodies that has a diversity of the tuning mechanisms within genetic and epigenetic levels in confrontation with environmental exposures. Disorders because of disturbed humoral immunity are linked with dysregulation of feedback-regulated signaling and the dynamic of immune components that determine the overall response. Food products, mainly herbal components have a significant role in tailoring the immune system micro-ecosystem which can diversify the adaptive nature of humoral immunity. Herein, we review the current evidence-based approaches for the impact of medicinal herbs on humoral immunity signaling and antibody production with a focus on immunotherapeutic applications.
人体免疫系统是一个具有高度生物学复杂性的动态多尺度系统。体液免疫作为适应性免疫的主要分支，其特征在于 B 淋巴细胞的分化阶段，产生最终的抗体产物，在与环境暴露的对抗中，具有遗传和表观遗传水平上的多样性调节机制。由于体液免疫失调引起的疾病与反馈调节信号的失调以及决定整体反应的免疫成分的动态有关。食品产品，主要是草药成分，在塑造免疫系统微生态系统方面发挥着重要作用，这可以使体液免疫的适应性多样化。在此，我们综述了基于循证的方法，探讨了草药对体液免疫信号和抗体产生的影响，重点介绍了免疫治疗应用。
