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风湿科主导的妊娠门诊:以患者为中心的方法。

Rheumatology-led pregnancy clinic: patient-centred approach.

机构信息

King's College London, London, UK.

Rheumatology Department, North Middlesex University Hospital, London, UK.

出版信息

Clin Rheumatol. 2021 Oct;40(10):3875-3882. doi: 10.1007/s10067-021-05690-y. Epub 2021 Mar 24.

Abstract

Autoimmune rheumatic diseases (ARDs), which include all types of inflammatory arthritis as well as systemic Lupus, are known to have a detrimental effect on both fertility and pregnancy outcomes. Consequently, reproductive health care is considered a principle constituent of comprehensive care for all patients with rheumatic ailments seen in the standard practice. Whilst pregnancy-associated complications have been reported in lupus, rheumatoid arthritis, and Sjogren's syndrome, in some conditions such as lupus, antiphospholipid syndrome, inflammatory myopathies, and vasculitis, the pregnancy may accelerate the disease progression. Furthermore, the activity of some diseases such as lupus and antiphospholipid syndrome may be augmented by some contraceptive methods. Therapeutically, some patients are prescribed medications, such as methotrexate and mycophenolate which have potentially teratogenic effect. Therefore, to be able to help those patients, family planning should be patient-centred with decision-making tailored to the individual's disease status. For those healthcare professionals interested in reproductive health care for their patients living with autoimmune rheumatic diseases, this review summarizes the available information in the literature and offers practical suggestions of patient-centred care in a dedicated rheumatology-led pregnancy clinic. Key Points • Autoimmune disorders, particularly systemic inflammatory rheumatic diseases, affect many women, often during childbearing age. • Pregnancies in this cohort of patients with rheumatic diseases is considered to be of high risk, because of the potential for complications during periods of active disease and the possible impact of medications used on both the pregnancy outcomes as well as the baby. • There are high chances of successful and safe pregnancies particularly if pre-pregnancy planning and screening for maternal and fetal risks are undertaken, and pregnancy takes place while the disease is well controlled. Encouraging the patients, who are in their childbearing period, to initiate discussions about family planning and pregnancy, with their treating rheumatologists, would be an ideal approach to close this gap of information exchange. • Targeted patients' education is expected to improve the information quality and promote more collaborative decision-making with regard to motherhood and healthcare choices.

摘要

自身免疫性风湿病(ARDs)包括所有类型的炎性关节炎以及系统性红斑狼疮,已知其对生育和妊娠结局均有不良影响。因此,生殖健康护理被认为是标准实践中所有风湿性疾病患者综合护理的重要组成部分。虽然狼疮、类风湿关节炎和干燥综合征已报道妊娠相关并发症,但在某些情况下,如狼疮、抗磷脂综合征、炎性肌病和血管炎,妊娠可能会加速疾病进展。此外,某些疾病(如狼疮和抗磷脂综合征)的活动可能会因某些避孕方法而增强。在治疗方面,一些患者被开处方使用具有潜在致畸作用的药物,如甲氨蝶呤和霉酚酸酯。因此,为了能够帮助这些患者,计划生育应该以患者为中心,根据个体疾病状况量身定制决策。对于那些对自身免疫性风湿病患者生殖健康护理感兴趣的医疗保健专业人员,本综述总结了文献中的现有信息,并提供了在专门的风湿病主导的妊娠诊所中以患者为中心的护理的实用建议。要点 • 自身免疫性疾病,特别是系统性炎症性风湿病,影响许多女性,通常在生育年龄。 • 患有风湿性疾病的这一组患者的妊娠被认为是高风险的,因为在疾病活跃期间可能会出现并发症,以及用于治疗疾病的药物可能会对妊娠结局和婴儿产生影响。 • 如果进行了孕前计划和母婴风险筛查,并在疾病得到良好控制时妊娠,那么成功和安全的妊娠机会很高。鼓励处于生育期的患者与治疗风湿病的医生讨论计划生育和妊娠问题,这将是缩小信息交流差距的理想方法。 • 预计有针对性的患者教育将提高信息质量,并促进在生育和医疗保健选择方面进行更多的协作决策。

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