van Heek Lutz, Staudacher Christiane, Faust Michael, Chiapponi Costanza, Mettler Jasmin, Schmidt Matthias, Drzezga Alexander, Dietlein Markus, Kobe Carsten
Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Center for Endocrinology, Diabetes and Preventive Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Nuklearmedizin. 2021 Aug;60(4):266-271. doi: 10.1055/a-1400-3522. Epub 2021 Mar 23.
Hashimoto's thyroiditis is a common disease that also affects pregnant women. We analyzed to what extent the inflammatory process of Hashimoto's thyroiditis changes with iodine prophylaxis in pregnant women. The target for immunologic activity was levels of thyroid antibodies (TPO).
The data were collected retrospectively from 20 consecutive, pregnant patients who had been diagnosed with Hashimoto's thyroiditis between 01.12.2012 and 01.12.2014 and had received iodine supplementation with 100 µg (n = 1) or 150 µg (n = 19). At least two measurements of TPO antibody levels taken during pregnancy and one after pregnancy were evaluated for each patient in the study group.
At the end of pregnancy, the average TPO antibody level for the 20 patients studied was 137 IU/ml (+/-214 IU/ml), the lowest being 16 IU/ml and the highest 1000 IU/ml. Despite iodine prophylaxis, levels of TPO antibodies decreased in 18 patients during pregnancy, falling below the reference value of 35 IU/ml in 5 cases. However, in one patient TPO antibodies increased from 60 IU/ml to 237 IU/ml during pregnancy while in another, levels remained constant at 1000 IU/ml.
Iodine prophylaxis in pregnant women, taken at a dose of 100 or 150 μg daily was shown to have no negative systemic effects on Hashimoto's thyroiditis in a group of pregnant women with increased TPO levels, and can therefore be recommended for expectant mothers, including those with this disease.
桥本甲状腺炎是一种常见疾病，也会影响孕妇。我们分析了孕妇碘预防措施对桥本甲状腺炎炎症过程的影响程度。免疫活性的指标是甲状腺抗体（TPO）水平。
回顾性收集了2012年12月1日至2014年12月1日期间连续诊断为桥本甲状腺炎且接受100μg（n = 1）或150μg（n = 19）碘补充的20名孕妇的数据。对研究组中的每位患者，评估孕期至少两次以及产后一次的TPO抗体水平测量值。
在妊娠末期，所研究的20名患者的平均TPO抗体水平为137IU/ml（±214IU/ml），最低为16IU/ml，最高为1000IU/ml。尽管进行了碘预防，但18名患者在孕期TPO抗体水平下降，其中5例降至35IU/ml的参考值以下。然而，1例患者孕期TPO抗体从60IU/ml升至237IU/ml，另1例患者的水平维持在1000IU/ml不变。
在一组TPO水平升高的孕妇中，每日服用100或150μg剂量的碘预防措施对桥本甲状腺炎没有负面的全身影响，因此可推荐给包括患有该疾病的孕妇在内的准妈妈。
