G. A. Razuvaev Institute of Organometallic Chemistry of Russian Academy of Sciences, Tropinina 49, Nizhny Novgorod, 603950, Russian Federation.
Privolzhsky Research Medical University of the Ministry of Health Care of the Russian Federation, Minin and Pozharsky Square 10/1, Nizhny Novgorod, 603005, Russian Federation.
Macromol Biosci. 2021 May;21(5):e2000402. doi: 10.1002/mabi.202000402. Epub 2021 Mar 23.
Porous polymer materials derived from poly(ethylene glycol dimethacrylate) (poly-EGDMA) and antibiotic containing polylactide (PLA) are obtained for the first time. Porous poly-EGDMA monoliths with a system of open interconnected pores are synthesized by a visible light-induced radical polymerization of EGDMA in the presence of 70 wt% of porogenic agent, e.g., 1-butanol, 1-hexanol, 1-octanol, or cyclohexanol. The porosity of the obtained polymers is 75-78%. A modal pore size depends on the nature of the porogen and varies from 0.5 µm (cyclohexanol) to 12 µm (1-butanol). The polymer matrix made with 1-butanol features the presence of pores ranging from 1 to 100 µm. The pore surface of poly-EGDMA matrices is inlayered with poly-D,L-lactide (M 23 × 10 Da, PDI 1.31). The PLA-modified poly-EGDMA retains a porous structure that is similar to the initial poly-EGDMA but with improved strength characteristics. The presence of antibiotic containing PLA ensures a high and continuous antibacterial activity of the hybrid polymeric material for 7 days. The nontoxicity of all the porous matrices studied makes them promising for clinical tests as osteoplastic materials.
首次获得了由聚（乙二醇二甲基丙烯酸酯）（poly-EGDMA）和含抗生素的聚乳酸（PLA）衍生的多孔聚合物材料。通过在 70wt%致孔剂（例如 1-丁醇、1-己醇、1-辛醇或环己醇）存在下，用光引发 EGDMA 的自由基聚合，合成了具有开放互联孔系统的多孔聚-EGDMA 单体。所得聚合物的孔隙率为 75-78%。模态孔径取决于致孔剂的性质，从 0.5μm（环己醇）变化到 12μm（1-丁醇）。用 1-丁醇制成的聚合物基质具有 1 至 100μm 的孔径。聚-EGDMA 基质的孔表面为聚-D，L-乳酸（M 23×10 Da，PDI 1.31）。含抗生素的 PLA 改性聚-EGDMA 保留了类似于初始聚-EGDMA 的多孔结构，但具有改善的强度特性。含有抗生素的 PLA 的存在确保了混合聚合物材料具有高且持续的抗菌活性，持续 7 天。研究的所有多孔基质均无毒性，这使得它们有望作为骨形成材料进行临床测试。
