Aleynik Diana Ya, Zhivtscov Oleg P, Yudin Vladimir V, Kovylin Roman S, Komarov Roman N, Charykova Irina N, Linkova Daria D, Rubtsova Yulia P, Guseva Maria S, Vasyagina Tatyana I, Morozov Alexander G, Chesnokov Sergey A, Egorikhina Marfa N
Federal State Budgetary Educational Institution of Higher Education, Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, Minin and Pozharsky Square 10/1, Nizhny Novgorod 603005, Russia.
G. A. Razuvaev Institute of Organometallic Chemistry of Russian Academy of Sciences, Tropinina 49, Nizhny Novgorod 603950, Russia.
Polymers (Basel). 2024 Apr 20;16(8):1165. doi: 10.3390/polym16081165.
This paper provides a study of two bone substitutes: a hybrid porous polymer and an osteoplastic matrix based on a bovine-derived xenograft. Both materials are porous, but their pore characteristics are different. The osteoplastic matrix has pores of 300-600 µm and the hybrid polymer has smaller pores, generally of 6-20 µm, but with some pores up to 100 µm across. SEM data confirmed the porometry results and demonstrated the different structures of the materials. Therefore, both materials were characterized by an interconnected porous structure and provided conditions for the adhesion and vital activity of human ASCs in vitro. In an experimental model of rabbit shin bone defect, it was shown that, during the 6-month observation period, neither of the materials caused negative reactions in the experimental animals. By the end of the observation period, restoration of the defects in animals in both groups was completed, and elements of both materials were preserved in the defect areas. Data from morphological examinations and CT data demonstrated that the rate of rabbit bone tissue regeneration with the hybrid polymer was comparable to that with the osteoplastic matrix. Therefore, the hybrid polymer has good potential for use in further research and improvement in biomedical applications.
一种是混合多孔聚合物，另一种是基于牛源异种移植物的骨成形基质。两种材料均为多孔结构，但其孔隙特征不同。骨成形基质的孔隙为300 - 600微米，混合聚合物的孔隙较小，一般为6 - 20微米，但有些孔隙直径可达100微米。扫描电子显微镜（SEM）数据证实了孔隙率测量结果，并展示了材料的不同结构。因此，两种材料均具有相互连通的多孔结构，为人类脂肪干细胞（ASCs）在体外的黏附和活性提供了条件。在兔胫骨缺损的实验模型中，结果表明，在6个月的观察期内，两种材料均未在实验动物中引起不良反应。到观察期结束时，两组动物的缺损均已修复，缺损区域均保留了两种材料的成分。形态学检查数据和CT数据表明，混合聚合物促进兔骨组织再生的速率与骨成形基质相当。因此，混合聚合物在生物医学应用的进一步研究和改进方面具有良好的应用潜力。
