Allen D G, Davey D A, Dacre D
Department of Obstetrics and Gynaecology, University of Cape Town.
S Afr Med J. 1988 May 7;73(9):518-21.
Stabilised human serum 500 ml was infused intravenously over 90 minutes in 14 hypertensive women in late pregnancy, and the haemodynamic changes were investigated and compared with those in 7 similar women who were not treated. There was a significant mean increase of 1,85 l in plasma volume, a decrease in diastolic and systolic blood pressure, and an increase in central venous pressure (CVP), pulse pressure and pulse rate in the treated group at 2 hours but not in the control group. After 24 hours most of the observations were not significantly different from the pretreatment levels except the CVP and pulse rate measurements which were still significantly raised. The CVP measurements in the hypertensive women before treatment were relatively low compared with those reported in normal women in late pregnancy. It is suggested that there may be an under-filling of the circulation in pregnancy hypertension and that plasma volume expansion may have an important therapeutic effect by increasing cardiac output and renal and uterine blood flow.
对14名妊娠晚期高血压妇女静脉输注500毫升稳定化人血清，历时90分钟，研究其血流动力学变化，并与7名未接受治疗的相似妇女进行比较。治疗组在2小时时血浆量平均显著增加1.85升，舒张压和收缩压下降，中心静脉压（CVP）、脉压和脉搏率升高，而对照组无此变化。24小时后，除CVP和脉搏率测量值仍显著升高外，大多数观察结果与治疗前水平无显著差异。与妊娠晚期正常妇女的报道相比，高血压妇女治疗前的CVP测量值相对较低。提示妊娠高血压可能存在循环血容量不足，血浆量扩充可能通过增加心输出量以及肾和子宫血流量而具有重要的治疗作用。
