Gallery E D, Hunyor S N, Györy A Z
Q J Med. 1979 Oct;48(192):593-602.
The role of plasma volume in hypertension in pregnancy (pre-eclampsia) was investigated. Significant volume expansion from non-pregnant levels (16.5 +/- 1.60 ml/cm height) was present throughout pregnancy in 189 normal women, reaching 23.1 +/- 1.21 ml/cm at 33-36 weeks amenorrhoea. In another 40 initially normotensive pregnant women who developed hypertension, similar early volume expansion was followed by significant volume contraction in the third trimester, before evaluation of blood pressure in 29 (20.6 +/- 1.26 ml/cm), after it in 11 (18.6 +/- 1.27 ml/cm). Equivalent volume contraction was present in another 44 women studied only after hypertension developed in the third trimester. Oedema had no value as a clinical sign. In another 30 women with chronic hypertension, blood pressure was inversely related to plasma volume (r = 0.822) and to fetal growth (r = -0.710), which was directly related to plasma volume (r = 0.701). Plasma volume depletion plays a significant role in hypertension in pregnancy.
对血浆容量在妊娠期高血压（先兆子痫）中的作用进行了研究。189名正常孕妇在整个孕期血浆容量均从非孕期水平（16.5±1.60ml/cm身高）显著增加，在停经33 - 36周时达到23.1±1.21ml/cm。在另外40名最初血压正常但后来患高血压的孕妇中，早期血浆容量也有类似增加，随后在孕晚期出现显著的容量收缩，其中29名（20.6±1.26ml/cm）在评估血压之前出现，11名（18.6±1.27ml/cm）在评估血压之后出现。在另外44名仅在孕晚期出现高血压后才进行研究的女性中也出现了同等程度的容量收缩。水肿作为一种临床体征并无价值。在另外30名慢性高血压女性中，血压与血浆容量呈负相关（r = 0.822），与胎儿生长呈负相关（r = -0.710），而胎儿生长与血浆容量呈正相关（r = 0.701）。血浆容量减少在妊娠期高血压中起重要作用。
